BACKGROUND: Using phase analysis of gated single photon emission computed tomography (SPECT) imaging, we examined the relation between myocardial perfusion, degree of electrical dyssynchrony, and degree of SPECT-derived mechanical dyssynchrony in patients with left ventricular (LV) dysfunction. METHODS AND RESULTS: We retrospectively examined 125 patients with LV dysfunction and ejection fraction of 35% or lower. Fourier analysis converts regional myocardial counts into a continuous thickening function, allowing resolution of phase of onset of myocardial thickening. The SD of LV phase distribution (phase SD) and histogram bandwidth describe LV phase dispersion as a measure of dyssynchrony. Heart failure (HF) patients with perfusion abnormalities have higher degrees of dyssynchrony measured by median phase SD (45.5 degrees vs 27.7 degrees, P < .0001) and bandwidth (117.0 degrees vs 73.0 degrees, P = .0006). HF patients with prolonged QRS durations have higher degrees of dyssynchrony measured by median phase SD (54.1 degrees vs 34.7 degrees, P < .0001) and bandwidth (136.5 degrees vs 99.0 degrees, P = .0005). Mild to moderate correlations exist between QRS duration and phase analysis indices of phase SD (r = 0.50) and bandwidth (r = 0.40). Mechanical dyssynchrony (phase SD >43 degrees) was 43.2%. CONCLUSIONS: HF patients with perfusion abnormalities or prolonged QRS durations have higher degrees of mechanical dyssynchrony. Gated SPECT myocardial perfusion imaging can quantify myocardial function, perfusion, and dyssynchrony and may help in evaluating patients for cardiac resynchronization therapy.
BACKGROUND: Using phase analysis of gated single photon emission computed tomography (SPECT) imaging, we examined the relation between myocardial perfusion, degree of electrical dyssynchrony, and degree of SPECT-derived mechanical dyssynchrony in patients with left ventricular (LV) dysfunction. METHODS AND RESULTS: We retrospectively examined 125 patients with LV dysfunction and ejection fraction of 35% or lower. Fourier analysis converts regional myocardial counts into a continuous thickening function, allowing resolution of phase of onset of myocardial thickening. The SD of LV phase distribution (phase SD) and histogram bandwidth describe LV phase dispersion as a measure of dyssynchrony. Heart failure (HF) patients with perfusion abnormalities have higher degrees of dyssynchrony measured by median phase SD (45.5 degrees vs 27.7 degrees, P < .0001) and bandwidth (117.0 degrees vs 73.0 degrees, P = .0006). HF patients with prolonged QRS durations have higher degrees of dyssynchrony measured by median phase SD (54.1 degrees vs 34.7 degrees, P < .0001) and bandwidth (136.5 degrees vs 99.0 degrees, P = .0005). Mild to moderate correlations exist between QRS duration and phase analysis indices of phase SD (r = 0.50) and bandwidth (r = 0.40). Mechanical dyssynchrony (phase SD >43 degrees) was 43.2%. CONCLUSIONS: HF patients with perfusion abnormalities or prolonged QRS durations have higher degrees of mechanical dyssynchrony. Gated SPECT myocardial perfusion imaging can quantify myocardial function, perfusion, and dyssynchrony and may help in evaluating patients for cardiac resynchronization therapy.
Authors: James A White; Raymond Yee; Xiaping Yuan; Andrew Krahn; Allan Skanes; Michele Parker; George Klein; Maria Drangova Journal: J Am Coll Cardiol Date: 2006-10-31 Impact factor: 24.094
Authors: Cheuk-Man Yu; Yat-Sun Chan; Qing Zhang; Gabriel W K Yip; Chi-Kin Chan; Leo C C Kum; LiWen Wu; Alex Pui-Wai Lee; Yat-Yin Lam; Jeffrey Wing-Hong Fung Journal: J Am Coll Cardiol Date: 2006-12-05 Impact factor: 24.094
Authors: Jeffrey W H Fung; Q Zhang; Gabriel W K Yip; Joseph Y S Chan; Hamish C K Chan; Cheuk M Yu Journal: J Cardiovasc Electrophysiol Date: 2006-09-20
Authors: Maureen M Henneman; Ji Chen; Petra Dibbets-Schneider; Marcel P Stokkel; Gabe B Bleeker; Claudia Ypenburg; Ernst E van der Wall; Martin J Schalij; Ernest V Garcia; Jeroen J Bax Journal: J Nucl Med Date: 2007-06-15 Impact factor: 10.057
Authors: Gabe B Bleeker; Eduard R Holman; Paul Steendijk; Eric Boersma; Ernst E van der Wall; Martin J Schalij; Jeroen J Bax Journal: J Am Coll Cardiol Date: 2006-11-09 Impact factor: 24.094
Authors: Mark A Trimble; Salvador Borges-Neto; Stuart Smallheiser; Ji Chen; Emily F Honeycutt; Linda K Shaw; Jaekyeong Heo; Robert A Pagnanelli; E Lindsey Tauxe; Ernest V Garcia; Fabio Esteves; Frank Seghatol-Eslami; G Neal Kay; Ami E Iskandrian Journal: J Nucl Cardiol Date: 2007-04-18 Impact factor: 5.952
Authors: Maureen M Henneman; Ji Chen; Claudia Ypenburg; Petra Dibbets; Gabe B Bleeker; Eric Boersma; Marcel P Stokkel; Ernst E van der Wall; Ernest V Garcia; Jeroen J Bax Journal: J Am Coll Cardiol Date: 2007-04-05 Impact factor: 24.094
Authors: Wael AlJaroudi; Wael A Jaber; Richard A Grimm; Thomas Marwick; Manuel D Cerqueira Journal: Int J Cardiovasc Imaging Date: 2011-10-18 Impact factor: 2.357
Authors: Wael AlJaroudi; Ji Chen; Wael A Jaber; Steven G Lloyd; Manuel D Cerqueira; Thomas Marwick Journal: Circ Cardiovasc Imaging Date: 2011-05 Impact factor: 7.792
Authors: Daniel R Ludwig; Mati Friehling; Erik B Schelbert; David Schwartzman Journal: Eur J Nucl Med Mol Imaging Date: 2013-11-09 Impact factor: 9.236
Authors: Allen E Atchley; Dalane W Kitzman; David J Whellan; Ami E Iskandrian; Stephen J Ellis; Robert A Pagnanelli; Andrew Kao; Khaled Abdul-Nour; Christopher M O'Connor; Greg Ewald; William E Kraus; Salvador Borges-Neto Journal: Am Heart J Date: 2009-10 Impact factor: 4.749
Authors: Ji Chen; Mark J Boogers; Mark M Boogers; Jeroen J Bax; Prem Soman; Ernest V Garcia Journal: Curr Cardiol Rep Date: 2010-03 Impact factor: 2.931