Literature DB >> 18760601

Phenylethyl cinnamides: a new series of alpha-glucosidase inhibitors from the leaves of Aegle marmelos.

Preecha Phuwapraisirisan1, Thanchanok Puksasook, Jonkolnee Jong-Aramruang, Udom Kokpol.   

Abstract

A series of phenylethyl cinnamides, which included new compounds named anhydromarmeline, aegelinosides A and B, were isolated from Aegle marmelos leaves as alpha-glucosidase inhibitors. The structures of new compounds were characterized by spectroscopic data and chemical degradation. Of compounds isolated, anhydroaegeline revealed the most potent inhibitory effect against alpha-glucosidase with IC(50) value of 35.8 microM. The present result also supports ethnopharmacological use of A. marmelos as a remedy for diabetes mellitus.

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Year:  2008        PMID： 18760601     DOI： 10.1016/j.bmcl.2008.08.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Semisynthetic studies identify mitochondria poisons from botanical dietary supplements--geranyloxycoumarins from Aegle marmelos.

Authors:  Jun Li; Fakhri Mahdi; Lin Du; Mika B Jekabsons; Yu-Dong Zhou; Dale G Nagle
Journal:  Bioorg Med Chem       Date:  2013-02-04       Impact factor: 3.641

2.  Mitochondrial respiration inhibitors suppress protein translation and hypoxic signaling via the hyperphosphorylation and inactivation of translation initiation factor eIF2α and elongation factor eEF2.

Authors:  Jun Li; Fakhri Mahdi; Lin Du; Sandipan Datta; Dale G Nagle; Yu-Dong Zhou
Journal:  J Nat Prod       Date:  2011-08-29       Impact factor: 4.050

3.  Dietary supplementation with Piper sarmentosum extract on gut health of chickens infected with Eimeria tenella.

Authors:  Fareed Uddin Memon; Yunqiao Yang; Ahmed M Soliman; Feifei Lv; Nasir Rajput; Geyin Zhang; Mirza Baber Baig; Yuhan Wang; Hongbin Si
Journal:  Trop Anim Health Prod       Date:  2021-10-05       Impact factor: 1.559

4.  Qualitative and quantitative ethnobotanical study of the Pangkhua community in Bilaichari Upazilla, Rangamati District, Bangladesh.

Authors:  Mohammad Omar Faruque; Gang Feng; Md Nurul Amin Khan; James W Barlow; Umme Ruman Ankhi; Sheng Hu; M Kamaruzzaman; Shaikh Bokhtear Uddin; Xuebo Hu
Journal:  J Ethnobiol Ethnomed       Date:  2019-02-05       Impact factor: 2.733

5.  Screening natural product extracts for potential enzyme inhibitors: protocols, and the standardisation of the usage of blanks in α-amylase, α-glucosidase and lipase assays.

Authors:  Chintha Lankatillake; Shiqi Luo; Matthew Flavel; George Binh Lenon; Harsharn Gill; Tien Huynh; Daniel Anthony Dias
Journal:  Plant Methods       Date:  2021-01-06       Impact factor: 4.993

6.  Anti-Neuroinflammatory Components from Clausena lenis Drake.

Authors:  Si-Si Zhu; Yi-Fan Zhang; Meng Ding; Ke-Wu Zeng; Peng-Fei Tu; Yong Jiang
Journal:  Molecules       Date:  2022-03-18       Impact factor: 4.411
  6 in total

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