STUDY DESIGN: Case description. OBJECTIVES: To report a rare case of intraosseous malignant peripheral nerve sheath tumors (MPNST), and review the pertinent medical literature. SUMMARY OF BACKGROUND DATA: The spinal MPNST that develops from spinal nerve roots and secondary bony erosion is well-known entity. However, primary intraosseous MPNSTs of the spine are extremely rare. METHODS: A 41-year-old male presented with a 1-month history of radiating pain to his right shoulder and arm. Magnetic resonance images showed a large extradural mass extending from C6 to T1 with destruction of the posterior elements of C6, C7, and T1. Complete excision of the tumor and posterior stabilization were performed through a posterior approach. The tumor was noted to originate from the posterior element of C7. RESULTS: The histopathology was diagnostic for a MPNST. Adjuvant chemotherapy was administered after surgery. The patient remained symptom-free for 30 months after surgery without local recurrence or metastasis. CONCLUSION: We report an intraosseous MPNST of the cervical spine. Complete surgical excision and adjuvant chemotherapy resulted in a good functional outcome. MPNST should be added to the differential diagnosis of primary bone tumors causing spinal cord compression.
STUDY DESIGN: Case description. OBJECTIVES: To report a rare case of intraosseous malignant peripheral nerve sheath tumors (MPNST), and review the pertinent medical literature. SUMMARY OF BACKGROUND DATA: The spinal MPNST that develops from spinal nerve roots and secondary bony erosion is well-known entity. However, primary intraosseous MPNSTs of the spine are extremely rare. METHODS: A 41-year-old male presented with a 1-month history of radiating pain to his right shoulder and arm. Magnetic resonance images showed a large extradural mass extending from C6 to T1 with destruction of the posterior elements of C6, C7, and T1. Complete excision of the tumor and posterior stabilization were performed through a posterior approach. The tumor was noted to originate from the posterior element of C7. RESULTS: The histopathology was diagnostic for a MPNST. Adjuvant chemotherapy was administered after surgery. The patient remained symptom-free for 30 months after surgery without local recurrence or metastasis. CONCLUSION: We report an intraosseous MPNST of the cervical spine. Complete surgical excision and adjuvant chemotherapy resulted in a good functional outcome. MPNST should be added to the differential diagnosis of primary bone tumors causing spinal cord compression.
Authors: V R Roopesh Kumar; Venkatesh S Madhugiri; Gopalakrishnan M Sasidharan; C V Shankar Ganesh; Sudheer Kumar Gundamaneni Journal: Eur Spine J Date: 2013-11-20 Impact factor: 3.134
Authors: Leila Metoui; Faïda Ajili; Mouna Maiza; Mehdi Ben Ammar; Imen Gharsallah; Issam M'sakni; Bassem Louzir; Salah Othmani Journal: Case Rep Med Date: 2013-12-05
Authors: Zachary W Veitch; Samir Fasih; Anthony M Griffin; Esmail M Al-Ezzi; Abha A Gupta; Peter C Ferguson; Jay S Wunder; Albiruni R Abdul Razak Journal: Cancer Med Date: 2020-10-16 Impact factor: 4.452
Authors: Bharti Devnani; Ahitagni Biswas; Sameer Bakhshi; Shah Alam Khan; Asit Ranjan Mridha; Shipra Agarwal Journal: Indian J Med Paediatr Oncol Date: 2017 Apr-Jun