Literature DB >> 18756382

TOR signaling in fission yeast.

Yoko Otsubo1, Masayuki Yamamato.   

Abstract

Fission yeast has two TOR kinases, Tor1 and Tor2. Recent studies have indicated that this microbe has a TSC/Rheb/TOR pathway like higher eukaryotes. Two TOR complexes, namely TORC1 and TORC2, have been identified in this yeast, as in budding yeast and mammals. Fission yeast TORC1, which contains Tor2, and TORC2, which contains Tor1, apparently have opposite functions with regard to the promotion of G1 arrest and sexual development. Rapamycin does not inhibit growth of wild-type fission yeast cells, unlike other eukaryotic cells, but precise analyses have revealed that rapamycin affects certain cellular functions involving TOR in this yeast. It appears that fission yeast has a potential to be an ideal model system to investigate the TOR signaling pathways.

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Year:  2008        PMID： 18756382     DOI： 10.1080/10409230802254911

Source DB:  PubMed          Journal:  Crit Rev Biochem Mol Biol        ISSN： 1040-9238            Impact factor:   8.250


  34 in total

1.  TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing.

Authors:  Daniel Rosel; Taruna Khurana; Amit Majithia; Xiuli Huang; Ramanath Bhandari; Alan R Kimmel
Journal:  J Cell Sci       Date:  2012-01-20       Impact factor: 5.285

2.  Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom.

Authors:  Cecelia A Shertz; Robert J Bastidas; Wenjun Li; Joseph Heitman; Maria E Cardenas
Journal:  BMC Genomics       Date:  2010-09-23       Impact factor: 3.969

3.  Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.

Authors:  Tomoka Murai; Yukiko Nakase; Keiko Fukuda; Yuji Chikashige; Chihiro Tsutsumi; Yasushi Hiraoka; Tomohiro Matsumoto
Journal:  Genetics       Date:  2009-07-20       Impact factor: 4.562

4.  Conservation of the Tsc/Rheb/TORC1/S6K/S6 Signaling in Fission Yeast.

Authors:  Akio Nakashima; Fuyuhiko Tamanoi
Journal:  Enzymes       Date:  2010

5.  TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Authors:  Thomas Laboucarié; Dylane Detilleux; Ricard A Rodriguez-Mias; Céline Faux; Yves Romeo; Mirita Franz-Wachtel; Karsten Krug; Boris Maček; Judit Villén; Janni Petersen; Dominique Helmlinger
Journal:  EMBO Rep       Date:  2017-10-27       Impact factor: 8.807

6.  Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.

Authors:  Akio Nakashima; Tatsuhiro Sato; Fuyuhiko Tamanoi
Journal:  J Cell Sci       Date:  2010-02-09       Impact factor: 5.285

7.  Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress.

Authors:  Junpei Ishiguro; Kenta Shibahara; Yumi Ueda; Kei Nakamura
Journal:  Mol Genet Genomics       Date:  2012-12-28       Impact factor: 3.291

8.  The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast.

Authors:  Hidekazu Takahashi; Xiaoying Sun; Makiko Hamamoto; Yoko Yashiroda; Minoru Yoshida
Journal:  J Biol Chem       Date:  2012-09-18       Impact factor: 5.157

9.  Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans.

Authors:  Yu-Ting Chen; Chia-Ying Lin; Pei-Wen Tsai; Cheng-Yao Yang; Wen-Ping Hsieh; Chung-Yu Lan
Journal:  Eukaryot Cell       Date:  2011-12-22

10.  Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans.

Authors:  Hyeseung Lee; Ami Khanal Lamichhane; H Martin Garraffo; Kyung J Kwon-Chung; Yun C Chang
Journal:  Mol Microbiol       Date:  2012-03-15       Impact factor: 3.501
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