OBJECTIVE: To evaluate whether [F-18] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can distinguish benign from malignant solitary pulmonary nodules (SPNs) with non-solid components. METHODS: [F-18] FDG-PET/CT scans were performed on 53 consecutive patients (30 men, 23 women; mean age 65 years) who had SPNs with non-solid components identified by CT screening for lung cancer. All patients underwent surgical resection, and all lesions were pathologically proved. Visual score, maximal, and mean standardized uptake value (SUV), and maximal and mean lesion-to-normal tissue count density ratio (LNR) were calculated in all lesions. In addition, clinical characteristics, laboratory test results, and CT findings were assessed. RESULTS: Benign SPNs with non-solid components had a higher uptake on [F-18] FDG-PET/CT. Visual score, maximal and mean SUV, and maximal and mean LNR were significantly higher in the benign when compared with the malignant SPNs (P < 0.001). When the cutoff of 1.5 was assigned for maximal SUV, the diagnostic performance of [F-18] FDG-PET/CT in predicting benign SPN revealed 100.0% sensitivity, 96.4% specificity, and 100.0% accuracy. CONCLUSIONS: [F-18] FDG-PET/CT is useful for the differential diagnosis of SPNs with non-solid components.
OBJECTIVE: To evaluate whether [F-18] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) can distinguish benign from malignant solitary pulmonary nodules (SPNs) with non-solid components. METHODS: [F-18] FDG-PET/CT scans were performed on 53 consecutive patients (30 men, 23 women; mean age 65 years) who had SPNs with non-solid components identified by CT screening for lung cancer. All patients underwent surgical resection, and all lesions were pathologically proved. Visual score, maximal, and mean standardized uptake value (SUV), and maximal and mean lesion-to-normal tissue count density ratio (LNR) were calculated in all lesions. In addition, clinical characteristics, laboratory test results, and CT findings were assessed. RESULTS: Benign SPNs with non-solid components had a higher uptake on [F-18] FDG-PET/CT. Visual score, maximal and mean SUV, and maximal and mean LNR were significantly higher in the benign when compared with the malignant SPNs (P < 0.001). When the cutoff of 1.5 was assigned for maximal SUV, the diagnostic performance of [F-18] FDG-PET/CT in predicting benign SPN revealed 100.0% sensitivity, 96.4% specificity, and 100.0% accuracy. CONCLUSIONS: [F-18] FDG-PET/CT is useful for the differential diagnosis of SPNs with non-solid components.
Authors: M Beth McCarville; Catherine Billups; Jianrong Wu; Robert Kaufman; Sue Kaste; Jamie Coleman; Susan Sharp; Helen Nadel; Martin Charron; Henrique Lederman; Steven Don; Stephen Shochat; Najat C Daw; Barry Shulkin Journal: AJR Am J Roentgenol Date: 2013-12 Impact factor: 3.959
Authors: Marcos Pretto Mosmann; Marcelle Alves Borba; Francisco Pires Negromonte de Macedo; Adriano de Araujo Lima Liguori; Arthur Villarim Neto; Kenio Costa de Lima Journal: Radiol Bras Date: 2016 Mar-Apr