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Literature DB >> 18756287

Replication licensing and cancer--a fatal entanglement?

Abstract

Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under- or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2008 PMID： 18756287 PMCID： PMC2577763 DOI： 10.1038/nrc2500

Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716

111 in total

Review 1. Checkpoint responses to replication fork barriers.

Authors: Sarah Lambert; Antony M Carr
Journal: Biochimie Date: 2004-12-10 Impact factor: 4.079

2. Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells.

Authors: Norman L Lehman; Emmy W Verschuren; Jerry Y Hsu; Athena M Cherry; Peter K Jackson
Journal: Cell Cycle Date: 2006-07-17 Impact factor: 4.534

3. Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.

Authors: Arkaitz Ibarra; Etienne Schwob; Juan Méndez
Journal: Proc Natl Acad Sci U S A Date: 2008-06-25 Impact factor: 11.205

4. Oncogenic activity of Cdc6 through repression of the INK4/ARF locus.

Authors: Susana Gonzalez; Peter Klatt; Sonia Delgado; Esther Conde; Fernando Lopez-Rios; Montserrat Sanchez-Cespedes; Juan Mendez; Francisco Antequera; Manuel Serrano
Journal: Nature Date: 2006-03-30 Impact factor: 49.962

5. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint.

Authors: J A Tercero; J F Diffley
Journal: Nature Date: 2001-08-02 Impact factor: 49.962

Review 6. Breaking news: high-speed race ends in arrest--how oncogenes induce senescence.

Authors: Raffaella Di Micco; Marzia Fumagalli; Fabrizio d'Adda di Fagagna
Journal: Trends Cell Biol Date: 2007-11-05 Impact factor: 20.808

7. Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.

Authors: Enbo Liu; Xianghong Li; Feng Yan; Qiping Zhao; Xiaohua Wu
Journal: J Biol Chem Date: 2004-03-05 Impact factor: 5.157

Review 8. The role of pre-replicative complex (pre-RC) components in oncogenesis.

Authors: Eric Lau; Toshiya Tsuji; Liping Guo; Shih-Hsin Lu; Wei Jiang
Journal: FASEB J Date: 2007-08-09 Impact factor: 5.191

9. Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins.

Authors: P J Gillespie; A Li; J J Blow
Journal: BMC Biochem Date: 2001-12-05 Impact factor: 4.059

10. Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C.

Authors: Barbara Di Fiore; Jonathon Pines
Journal: J Cell Biol Date: 2007-05-07 Impact factor: 10.539

112 in total

1. Quantitative proteomics reveals a "poised quiescence" cellular state after triggering the DNA replication origin activation checkpoint.

Authors: Claire Mulvey; Slavica Tudzarova; Mark Crawford; Gareth H Williams; Kai Stoeber; Jasminka Godovac-Zimmermann
Journal: J Proteome Res Date: 2010-10-01 Impact factor: 4.466

2. Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.

Authors: Jungoo Jee; Takeshi Mizuno; Katsuhiko Kamada; Hidehito Tochio; Yasumasa Chiba; Ken-Ichiro Yanagi; Gentaro Yasuda; Hidekazu Hiroaki; Fumio Hanaoka; Masahiro Shirakawa
Journal: J Biol Chem Date: 2010-03-24 Impact factor: 5.157

3. Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers.

Authors: Sara Rodriguez-Acebes; Ian Proctor; Marco Loddo; Alex Wollenschlaeger; Mohammed Rashid; Mary Falzon; A Toby Prevost; Richard Sainsbury; Kai Stoeber; Gareth H Williams
Journal: Am J Pathol Date: 2010-08-19 Impact factor: 4.307

4. Loss of DNA replication control is a potent inducer of gene amplification.

Authors: Brian M Green; Kenneth J Finn; Joachim J Li
Journal: Science Date: 2010-08-20 Impact factor: 47.728

5. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences.

Authors: Leonora Balaj; Ryan Lessard; Lixin Dai; Yoon-Jae Cho; Scott L Pomeroy; Xandra O Breakefield; Johan Skog
Journal: Nat Commun Date: 2011-02-01 Impact factor: 14.919

6. Multi-step loading of human minichromosome maintenance proteins in live human cells.

Authors: Ioanna-Eleni Symeonidou; Panagiotis Kotsantis; Vassilis Roukos; Maria-Anna Rapsomaniki; Hernán E Grecco; Philippe Bastiaens; Stavros Taraviras; Zoi Lygerou
Journal: J Biol Chem Date: 2013-10-24 Impact factor: 5.157

7. Human DNA helicase B interacts with the replication initiation protein Cdc45 and facilitates Cdc45 binding onto chromatin.

Authors: Jeannine Gerhardt; Gulfem D Guler; Ellen Fanning
Journal: Exp Cell Res Date: 2015-04-29 Impact factor: 3.905