BACKGROUND: The lymph node harvest from colorectal specimens is pivotal for patients with colorectal cancer (CRC), independent of N stage. AIMS: To determine whether the use of GEWF solution (glacial acetic acid, ethanol, distilled water and formaldehyde) could improve the lymph node harvest in CRC specimens. METHODS:Consecutive fresh colonic (n = 60) and rectal (n = 60) specimens from patients with primary CRC resected at Aarhus University Hospital THG between March 2006 and July 2007 were randomised to either conventional preparation or GEWF preparation and examined in a standard manner. RESULTS: For colonic as well as rectal specimens, the GEWF solution increased the mean lymph node harvest from 9 and 10 to 16 and 17 lymph nodes per specimen compared to conventional prepared specimens (p<0.001). Using the recommended threshold of 12 lymph nodes to ensure adequacy of nodal harvest, the adequacy increased from less than half to almost three quarters independent of tumour origin (p<0.037). The proportion of node-negative specimens was not significantly different between the two preparation groups. CONCLUSION: The use of GEWF solution in patients with CRC significantly increases the lymph node harvest of resected specimens.
RCT Entities:
BACKGROUND: The lymph node harvest from colorectal specimens is pivotal for patients with colorectal cancer (CRC), independent of N stage. AIMS: To determine whether the use of GEWF solution (glacial acetic acid, ethanol, distilled water and formaldehyde) could improve the lymph node harvest in CRC specimens. METHODS: Consecutive fresh colonic (n = 60) and rectal (n = 60) specimens from patients with primary CRC resected at Aarhus University Hospital THG between March 2006 and July 2007 were randomised to either conventional preparation or GEWF preparation and examined in a standard manner. RESULTS: For colonic as well as rectal specimens, the GEWF solution increased the mean lymph node harvest from 9 and 10 to 16 and 17 lymph nodes per specimen compared to conventional prepared specimens (p<0.001). Using the recommended threshold of 12 lymph nodes to ensure adequacy of nodal harvest, the adequacy increased from less than half to almost three quarters independent of tumour origin (p<0.037). The proportion of node-negative specimens was not significantly different between the two preparation groups. CONCLUSION: The use of GEWF solution in patients with CRC significantly increases the lymph node harvest of resected specimens.
Authors: K E Storli; K Søndenaa; B Furnes; I Nesvik; E Gudlaugsson; I Bukholm; G E Eide Journal: Tech Coloproctol Date: 2013-12-20 Impact factor: 3.781
Authors: Philipp Schrembs; Benedikt Martin; Matthias Anthuber; Gerhard Schenkirsch; Bruno Märkl Journal: PLoS One Date: 2018-08-10 Impact factor: 3.240