Literature DB >> 18751849

Osteoporosis and skeletal fractures.

Michael J Gardner1, Demetris Demetrakopoulos, Michael K Shindle, Matthew H Griffith, Joseph M Lane.   

Abstract

Osteoporosis affects millions of individuals worldwide, rendering them susceptible to fragility fractures of the spine, hip, and wrist and leading to significant morbidity, mortality, and economic cost. Given the substantial impact of osteoporosis on both patients and the medical community, it is imperative that physicians improve awareness and knowledge of osteoporosis in the setting of low-energy fractures. In this review, we provide information on effective means of preventing fragility fractures and introduce clinicians to issues pertinent to the patient who suffers an osteoporotic fracture. Prevention of fragility fractures centers around adequate mineral nutrition, including daily calcium and vitamin D supplementation, as well as prescription antiresorptive medications such as bisphosphonates or teriparatide therapy in severe cases, both of which have been shown to decrease future fracture risk. Balance and strength training also play important roles in the management of the osteoporotic patient, particularly following a low-energy fracture, and external hip protectors may be useful for certain patients. Kyphoplasty and vertebroplasty are two minimally invasive techniques that show great promise in the treatment of vertebral compression fractures, although questions regarding long-term biomechanical effects still exist. Traditionally, osteoporosis has been underdiagnosed and undertreated following a low-energy fracture in an elderly patient. Although treatment rates may be improving through public health initiatives, the majority of patients with osteoporosis remain inadequately treated. Perioperative intervention programs that focus on patient education about osteoporosis and treatment options lead to significant increases in intervention and treatment. Reducing the risk of skeletal fractures in patients susceptible to osteoporosis involves improved physician education on the risk factors and management of osteoporosis, as well as informing patients on the significance of dual-energy X-ray absorptiometry testing and medical treatment so that they may serve as their own healthcare advocates in this often-undertreated disease.

Entities:  

Year:  2006        PMID: 18751849      PMCID: PMC2504115          DOI: 10.1007/s11420-005-0137-8

Source DB:  PubMed          Journal:  HSS J        ISSN: 1556-3316


  96 in total

1.  Opinions and experiences in general practice on osteoporosis prevention, diagnosis and management.

Authors:  J C Taylor; B Sterkel; M Utley; M Shipley; S Newman; M Horton; H Fitz-Clarence
Journal:  Osteoporos Int       Date:  2001       Impact factor: 4.507

Review 2.  NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7-29, 2000: highlights of the conference.

Authors: 
Journal:  South Med J       Date:  2001-06       Impact factor: 0.954

3.  Percutaneous balloon kyphoplasty for the correction of spinal deformity in painful vertebral body compression fractures.

Authors:  Daphne J Theodorou; Stavroula J Theodorou; Timothy D Duncan; Steven R Garfin; Wade H Wong
Journal:  Clin Imaging       Date:  2002 Jan-Feb       Impact factor: 1.605

4.  Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group.

Authors:  J Reginster; H W Minne; O H Sorensen; M Hooper; C Roux; M L Brandi; B Lund; D Ethgen; S Pack; I Roumagnac; R Eastell
Journal:  Osteoporos Int       Date:  2000       Impact factor: 4.507

5.  Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.

Authors:  R M Neer; C D Arnaud; J R Zanchetta; R Prince; G A Gaich; J Y Reginster; A B Hodsman; E F Eriksen; S Ish-Shalom; H K Genant; O Wang; B H Mitlak
Journal:  N Engl J Med       Date:  2001-05-10       Impact factor: 91.245

6.  Coordination exercise and postural stability in elderly people: Effect of Tai Chi Chuan.

Authors:  A M Wong; Y C Lin; S W Chou; F T Tang; P Y Wong
Journal:  Arch Phys Med Rehabil       Date:  2001-05       Impact factor: 3.966

7.  Missing a therapeutic window of opportunity: an audit of patients attending a tertiary teaching hospital with potentially osteoporotic hip and wrist fractures.

Authors:  M D Smith; W Ross; M J Ahern
Journal:  J Rheumatol       Date:  2001-11       Impact factor: 4.666

8.  Intravenous zoledronic acid in postmenopausal women with low bone mineral density.

Authors:  Ian R Reid; Jacques P Brown; Peter Burckhardt; Zebulun Horowitz; Peter Richardson; Ulrich Trechsel; Albert Widmer; Jean-Pierre Devogelaer; Jean-Marc Kaufman; Philippe Jaeger; Jean-Jacques Body; Maria Luisa Brandi; Johann Broell; Raffaele Di Micco; Andrea Riccardo Genazzani; Dieter Felsenberg; Joachim Happ; Michael J Hooper; Jochen Ittner; Georg Leb; Hans Mallmin; Timothy Murray; Sergio Ortolani; Alessandro Rubinacci; Maria Saaf; Goran Samsioe; Leon Verbruggen; Pierre J Meunier
Journal:  N Engl J Med       Date:  2002-02-28       Impact factor: 91.245

9.  Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis. A study in immature rabbits.

Authors:  D G Little; M S Cornell; J Briody; C T Cowell; S Arbuckle; C M Cooke-Yarborough
Journal:  J Bone Joint Surg Br       Date:  2001-09

10.  Acceptance of hip protectors for hip fracture prevention in nursing homes.

Authors:  M Hubacher; A Wettstein
Journal:  Osteoporos Int       Date:  2001       Impact factor: 4.507

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  17 in total

Review 1.  Organic-inorganic composites for bone drug delivery.

Authors:  Chidambaram Soundrapandian; Biswanath Sa; Someswar Datta
Journal:  AAPS PharmSciTech       Date:  2009-10-20       Impact factor: 3.246

2.  Comparative study on the period of absolute bed rest of vertebral compression fracture.

Authors:  Kyung Han Cha; Tack Geun Cho; Chang Hyun Kim; Ho Kook Lee; Jae Gon Moon
Journal:  Korean J Spine       Date:  2013-09-30

3.  The use of routine non density calibrated clinical computed tomography data as a potentially useful screening tool for identifying patients with osteoporosis.

Authors:  Christopher John Burke; Manjiri M Didolkar; Huiman X Barnhart; Emily N Vinson
Journal:  Clin Cases Miner Bone Metab       Date:  2016-10-05

4.  Underdiagnosis of osteoporotic vertebral fractures in patients with fragility fractures: retrospective analysis of over 300 patients.

Authors:  Vanna Bottai; Stefano Giannotti; Gloria Raffaetà; Maurizio Mazzantini; Francesco Casella; Gaia De Paola; Agnese Menconi; Francesca Falossi; Giulio Guido
Journal:  Clin Cases Miner Bone Metab       Date:  2016-10-05

5.  Osteoporotic fracture and parathyroid hormone.

Authors:  Nabanita S Datta
Journal:  World J Orthop       Date:  2011-08-18

6.  Evaluation of a pulsed phase-locked loop system for noninvasive tracking of bone deformation under loading with finite element and strain analysis.

Authors:  Frederick Serra-Hsu; Jiqi Cheng; Ted Lynch; Yi-Xian Qin
Journal:  Physiol Meas       Date:  2011-07-15       Impact factor: 2.833

7.  The development of a clinical decision making algorithm for detection of osteoporotic vertebral compression fracture or wedge deformity.

Authors:  Matthew Roman; Christopher Brown; William Richardson; Robert Isaacs; Cameron Howes; Chad Cook
Journal:  J Man Manip Ther       Date:  2010-03

8.  MiR-142-5p promotes bone repair by maintaining osteoblast activity.

Authors:  Manli Tu; Juanjuan Tang; Hongbo He; Peng Cheng; Chao Chen
Journal:  J Bone Miner Metab       Date:  2016-04-16       Impact factor: 2.626

9.  The implantation of a Nickel-Titanium shape memory alloy ameliorates vertebral body compression fractures: a cadaveric study.

Authors:  Bo Chen; Yue-Huang Zheng; Tao Zheng; Chang-Hui Sun; Jiong Lu; Peng Cao; Jian-Hua Zhou
Journal:  Int J Clin Exp Med       Date:  2015-09-15

10.  Risedronate on two consecutive days per month.

Authors:  James E Frampton
Journal:  Drugs Aging       Date:  2009       Impact factor: 3.923

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