| Literature DB >> 18751702 |
Nikica Darabos1, Zeljka Hundric-Haspl, Miroslav Haspl, Alemka Markotic, Anela Darabos, Carsten Moser.
Abstract
The possibility of controlling the harmful intra-articular influence of elevated interleukin (IL)-1beta synovial fluid concentration after anterior cruciate ligament (ACL) surgery could be useful. We investigated the correlation between serum and synovial fluid IL-1beta levels following ACL reconstruction. We measured IL-1beta concentration periodically in three synovial fluid and four serum samples in each of 20 patients receiving either autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and several growth factors (group A) or placebo (group B). A decrease in IL-1beta synovial fluid concentration appeared to be more pronounced in absolute terms in group A. In eight patients serum IL-1beta was detected on the 6th postoperative day. In four of them whose synovial fluid levels were over 10 pg/ml on the 6th postoperative day, serum IL-1beta was detected on the 10th postoperative day. The results were different in group B. Correlation between serum and synovial fluid IL-1beta appearance persists in patients after ACL surgery and ACS application. This study is an example of ACS influence on the ACL healing process controlling the IL-1beta levels on the basis of the serum IL-1beta detection.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18751702 PMCID： PMC2899090 DOI： 10.1007/s00264-008-0649-1
Source DB: PubMed Journal: Int Orthop ISSN： 0341-2695 Impact factor: 3.075