Literature DB >> 1873825

Interleukin-1 is a mucus secretagogue.

V L Cohan1, A L Scott, C A Dinarello, R A Prendergast.   

Abstract

Explant cultures of mouse duodenum were used to show that interleukin-1 (IL-1) causes release of mucus from epithelial goblet cells. Our experiments made use of a newly described enzyme-linked lectin assay (ELLA) which employs enzyme-conjugated soybean agglutinin to detect mucus glycoproteins secreted from explant cultures of mouse duodenum. Supernatants from cultures of lipopolysaccharide-stimulated peritoneal macrophages as well as partially purified rabbit alveolar macrophage-derived IL-1 and human rIL-1 beta all induced mucus release in a rapid and dose-dependent fashion. This observation may be important for investigating a link between the immune response and mucus hypersecretion from inflamed intestinal mucosa.

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Year:  1991        PMID： 1873825     DOI： 10.1016/0008-8749(91)90364-h

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  11 in total

Review 1.  Mucin overproduction in chronic inflammatory lung disease.

Authors:  Hans-Peter Hauber; Susan C Foley; Qutayba Hamid
Journal:  Can Respir J       Date:  2006-09       Impact factor: 2.409

2.  Direct secretory effect of interleukin-1 via type I receptors in human colonic mucous epithelial cells (HT29-C1.16E).

Authors:  A Jarry; G Vallette; J E Branka; C Laboisse
Journal:  Gut       Date:  1996-02       Impact factor: 23.059

3.  Effectiveness of bombesin and Saccharomyces boulardii against the translocation of Candida albicans in the digestive tract in immunosuppressed rats.

Authors:  Cem Algin; Adnan Sahin; Nuri Kiraz; Varol Sahintürk; Enver Ihtiyar
Journal:  Surg Today       Date:  2005       Impact factor: 2.549

4.  Infection with Strongyloides venezuelensis induces transient airway eosinophilic inflammation, an increase in immunoglobulin E, and hyperresponsiveness in rats.

Authors:  Micheline R Silveira; Kênia P Nunes; Denise C Cara; Danielle G Souza; Ary Corrêa; Mauro M Teixeira; Deborah Negrão-Corrêa
Journal:  Infect Immun       Date:  2002-11       Impact factor: 3.441

5.  Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice.

Authors:  L L Shekels; R E Anway; J Lin; M W Kennedy; P Garside; C E Lawrence; S B Ho
Journal:  Dig Dis Sci       Date:  2001-08       Impact factor: 3.199

6.  Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E(1) and E(2) production by intestinal myofibroblasts.

Authors:  L E M Willemsen; M A Koetsier; S J H van Deventer; E A F van Tol
Journal:  Gut       Date:  2003-10       Impact factor: 23.059

7.  Effects of cytokines, without and with Helicobacter pylori components, on mucus secretion by cultured gastric epithelial cells.

Authors:  S Takahashi; E Nakamura; S Okabe
Journal:  Dig Dis Sci       Date:  1998-10       Impact factor: 3.199

8.  Goblet cell mucins as the selective barrier for the intestinal helminths: T-cell-independent alteration of goblet cell mucins by immunologically 'damaged' Nippostrongylus brasiliensis worms and its significance on the challenge infection with homologous and heterologous parasites.

Authors:  N Ishikawa; Y Horii; T Oinuma; T Suganuma; Y Nawa
Journal:  Immunology       Date:  1994-03       Impact factor: 7.397

Review 9.  Role of N-acetylcysteine in the management of COPD.

Authors:  Anna M Sadowska; J Verbraecken; K Darquennes; W A De Backer
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2006

Review 10.  Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies.

Authors:  Jensine A Grondin; Yun Han Kwon; Parsa Mehraban Far; Sabah Haq; Waliul I Khan
Journal:  Front Immunol       Date:  2020-09-04       Impact factor: 7.561
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