Literature DB >> 16983448

Mucin overproduction in chronic inflammatory lung disease.

Hans-Peter Hauber1, Susan C Foley, Qutayba Hamid.   

Abstract

Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.

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Year:  2006        PMID： 16983448      PMCID： PMC2683320          DOI： 10.1155/2006/901417

Source DB:  PubMed          Journal:  Can Respir J        ISSN： 1198-2241            Impact factor:   2.409


  148 in total

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