OBJECTIVE: To investigate whether pelvic organ prolapse (POP) is associated with collagen 3 alpha 1 (COL3A1) polymorphisms and other factors. METHODS: A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis. RESULTS: The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP. CONCLUSION: There may be an association between COL3A1 genotype and risk of POP.
OBJECTIVE: To investigate whether pelvic organ prolapse (POP) is associated with collagen 3 alpha 1 (COL3A1) polymorphisms and other factors. METHODS: A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1rs1800255 and COL3A1rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis. RESULTS: The distribution of the COL3A1rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1rs1800255 genotype AA were significantly associated with risk of POP. CONCLUSION: There may be an association between COL3A1 genotype and risk of POP.
Authors: Sabrina L Lince; Leon C van Kempen; Jeroen R Dijkstra; Joanna IntHout; Mark E Vierhout; Kirsten B Kluivers Journal: Int Urogynecol J Date: 2014-04-24 Impact factor: 2.894
Authors: Fernando Henrique Teixeira; César Eduardo Fernandes; Ricardo Peres do Souto; Emerson de Oliveira Journal: Int Urogynecol J Date: 2019-04-30 Impact factor: 2.894
Authors: Jennifer M Wu; Anthony G Visco; Elizabeth A Grass; Damian M Craig; Rebekah G Fulton; Carol Haynes; Cindy L Amundsen; Svati H Shah Journal: Am J Obstet Gynecol Date: 2012-01-31 Impact factor: 8.661
Authors: Kirsten B Kluivers; Jeroen R Dijkstra; Jan C M Hendriks; Sabrina L Lince; Mark E Vierhout; Léon C L van Kempen Journal: Int Urogynecol J Pelvic Floor Dysfunct Date: 2009-05-15
Authors: Jennifer M Wu; Anthony G Visco; Elizabeth A Grass; Damian M Craig; Rebekah G Fulton; Carol Haynes; Alison C Weidner; Svati H Shah Journal: Obstet Gynecol Date: 2012-09 Impact factor: 7.661
Authors: Pamela J Levin; Anthony G Visco; Svati H Shah; Rebekah G Fulton; Jennifer M Wu Journal: Female Pelvic Med Reconstr Surg Date: 2012 Sep-Oct Impact factor: 2.091
Authors: Renée M Ward; Digna R Velez Edwards; Todd Edwards; Ayush Giri; Rebecca N Jerome; Jennifer M Wu Journal: Am J Obstet Gynecol Date: 2014-04-12 Impact factor: 8.661