| Literature DB >> 18722117 |
Jing Fang1, Adwoa Akwabi-Ameyaw, Jonathan E Britton, Subba R Katamreddy, Frank Navas, Aaron B Miller, Shawn P Williams, David W Gray, Lisa A Orband-Miller, Jean Shearin, Dennis Heyer.
Abstract
A series of estrogen receptor ligands based on a 3-alkyl naphthalene scaffold was synthesized using an intramolecular enolate-alkyne cycloaromatization as the key step. Several of these compounds bearing a C6-OH group were shown to be high affinity ligands. All compounds had similar ERalpha and ERbeta binding affinity ranging from micromolar to low nanomolar.Entities:
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Year: 2008 PMID： 18722117 DOI： 10.1016/j.bmcl.2008.07.121
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823