Literature DB >> 18720530

Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors.

Carl C Schimanski1, Peter R Galle, Markus Moehler.   

Abstract

To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and SDF-1beta". CXCR4 expression correlated with dissemination of diverse gastrointestinal malignomas. The CXCR4 ligand SDF-1alpha might act as "chemorepellent" while SDF-1beta might act as "chemorepellent" for CTLs, inducing tumor rejection. The paracrine expression of SDF-1alpha was furthermore closely associated with neoangiogenesis. CXCR4 and its ligands influence the dissemination, immune rejection, and neoangiogenesis of human gastrointestinal cancers. Inhibition of CXCR4 might be an interesting therapeutic option.

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Year:  2008        PMID： 18720530      PMCID： PMC2739331          DOI： 10.3748/wjg.14.4721

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  35 in total

1.  Stromal derived factor-1 alpha (SDF-1 alpha) induces CD4+ T cell apoptosis via the functional up-regulation of the Fas (CD95)/Fas ligand (CD95L) pathway.

Authors:  M L Colamussi; P Secchiero; A Gonelli; M Marchisio; G Zauli; S Capitani
Journal:  J Leukoc Biol       Date:  2001-02       Impact factor: 4.962

2.  Increased level of stromal cell-derived factor-1 mRNA in peripheral blood mononuclear cells from children with AIDS-related lymphoma.

Authors:  S Sei; D P O'Neill; S K Stewart; Q Yang ; M Kumagai; A M Boler; M A Adde; S L Zwerski; L V Wood; D J Venzon; I T Magrath
Journal:  Cancer Res       Date:  2001-07-01       Impact factor: 12.701

3.  Expression of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1 in human brain tumors and their involvement in glial proliferation in vitro.

Authors:  Simone Barbero; Adriana Bajetto; Rudy Bonavia; Corola Porcile; Patrizia Piccioli; Paolo Pirani; Jean Louis Ravetti; Gianluigi Zona; Renato Spaziante; Tullio Florio; Gennaro Schettini
Journal:  Ann N Y Acad Sci       Date:  2002-11       Impact factor: 5.691

4.  Involvement of chemokine receptors in breast cancer metastasis.

Authors:  A Müller; B Homey; H Soto; N Ge; D Catron; M E Buchanan; T McClanahan; E Murphy; W Yuan; S N Wagner; J L Barrera; A Mohar; E Verástegui; A Zlotnik
Journal:  Nature       Date:  2001-03-01       Impact factor: 49.962

5.  Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation.

Authors:  W W Agace; A Amara; A I Roberts; J L Pablos; S Thelen; M Uguccioni; X Y Li; J Marsal; F Arenzana-Seisdedos; T Delaunay; E C Ebert; B Moser; C M Parker
Journal:  Curr Biol       Date:  2000-03-23       Impact factor: 10.834

6.  Cutting edge: stromal cell-derived factor-1 is a costimulator for CD4+ T cell activation.

Authors:  T Nanki; P E Lipsky
Journal:  J Immunol       Date:  2000-05-15       Impact factor: 5.422

Review 7.  [Stromal cell-derived factor 1 (SDF-1). Its structure and function].

Authors:  O Psenák
Journal:  Cas Lek Cesk       Date:  2001-06-21

8.  Diverse transcriptional response of CD4+ T cells to stromal cell-derived factor SDF-1: cell survival promotion and priming effects of SDF-1 on CD4+ T cells.

Authors:  Y Suzuki; M Rahman; H Mitsuya
Journal:  J Immunol       Date:  2001-09-15       Impact factor: 5.422

9.  Positive regulation of CXCR4 expression and signaling by interleukin-7 in CD4+ mature thymocytes correlates with their capacity to favor human immunodeficiency X4 virus replication.

Authors:  Nathalie Schmitt; Laurent Chêne; David Boutolleau; Marie-Thérèse Nugeyre; Eric Guillemard; Pierre Versmisse; Catherine Jacquemot; Françoise Barré-Sinoussi; Nicole Israël
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

10.  Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 (SDF-1): local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses.

Authors:  Kyriaki Dunussi-Joannopoulos; Krystyna Zuberek; Kathlene Runyon; Robert G Hawley; Anthony Wong; Jamie Erickson; Steve Herrmann; John P Leonard
Journal:  Blood       Date:  2002-09-01       Impact factor: 22.113
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  17 in total

1.  Reduced expression of CXCR4, a novel renal cancer stem cell marker, is associated with high-grade renal cell carcinoma.

Authors:  Arezoo Rasti; Maryam Abolhasani; Leili Saeednejad Zanjani; Mojgan Asgari; Mitra Mehrazma; Zahra Madjd
Journal:  J Cancer Res Clin Oncol       Date:  2016-09-16       Impact factor: 4.553

2.  CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer.

Authors:  Elda Righi; Satoshi Kashiwagi; Jianping Yuan; Michael Santosuosso; Pierre Leblanc; Rachel Ingraham; Benjamin Forbes; Beth Edelblute; Brian Collette; Deyin Xing; Magdalena Kowalski; Maria Cristina Mingari; Fabrizio Vianello; Michael Birrer; Sandra Orsulic; Glenn Dranoff; Mark C Poznansky
Journal:  Cancer Res       Date:  2011-07-08       Impact factor: 12.701

3.  Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer.

Authors:  Hyo Jin Lee; Song Mei Huang; Ha Yon Kim; Yoon Suk Oh; Ji Young Hwang; Zhe Long Liang; Jeong Ki Min; Hwan Jung Yun; Ji Young Sul; Samyong Kim; Deog Yeon Jo; Jin Man Kim
Journal:  Exp Ther Med       Date:  2011-03-16       Impact factor: 2.447

4.  Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies.

Authors:  Vilma Oliveira Frick; Claudia Rubie; Pirus Ghadjar; Sabrina K Faust; Mathias Wagner; Stefan Gräber; Martin K Schilling
Journal:  Tumour Biol       Date:  2010-09-24

5.  Phosphorylated CXCR4 expression has a positive prognostic impact in colorectal cancer.

Authors:  B Weixler; F Renetseder; I Facile; N Tosti; E Cremonesi; A Tampakis; T Delko; S Eppenberger-Castori; A Tzankov; G Iezzi; C Kettelhack; S D Soysal; U von Holzen; G C Spagnoli; L Terracciano; L Tornillo; Raoul A Droeser; S Däster
Journal:  Cell Oncol (Dordr)       Date:  2017-09-21       Impact factor: 6.730

6.  The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma.

Authors:  Tong Li; Hui Li; Yucheng Wang; Chansonette Harvard; Jia-Li Tan; Alfred Au; Zhidong Xu; David M Jablons; Liang You
Journal:  J Pathol       Date:  2011-01-05       Impact factor: 7.996

Review 7.  microRNAs and Corresponding Targets Involved in Metastasis of Colorectal Cancer in Preclinical In Vivo Models.

Authors:  Ulrich H Weidle; Ulrich Brinkmann; Simon Auslaender
Journal:  Cancer Genomics Proteomics       Date:  2020 Sep-Oct       Impact factor: 4.069

8.  Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer.

Authors:  Derek Zieker; Ingmar Königsrainer; Isabel Tritschler; Markus Löffler; Stefan Beckert; Frank Traub; Kay Nieselt; Sarah Bühler; Michael Weller; Jochen Gaedcke; Russell S Taichman; Hinnak Northoff; Björn L D M Brücher; Alfred Königsrainer
Journal:  Int J Cancer       Date:  2010-03-15       Impact factor: 7.396

9.  The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer.

Authors:  A Popple; L G Durrant; I Spendlove; P Rolland; I V Scott; S Deen; J M Ramage
Journal:  Br J Cancer       Date:  2012-03-13       Impact factor: 7.640

10.  High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma.

Authors:  Linhui Wang; Wei Chen; Li Gao; Qing Yang; Bing Liu; Zhenjie Wu; Yang Wang; Yinghao Sun
Journal:  World J Surg Oncol       Date:  2012-10-07       Impact factor: 2.754
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