Literature DB >> 18712624

In vitro permeation studies of nanoemulsions containing ketoprofen as a model drug.

Beom Su Kim1, Myoung Won, Kang Min Lee, Cheo Sang Kim.   

Abstract

We prepared a nanoemulsion system with benzyl alcohol/ ethanol/Solutol/smash(R) HS 15 /water. Ketoprofen was used as a model drug in this study. The nanoemulsions of this system evidenced a high degree of stability. The droplet diameter did not change over a period of at least 3 months. The nanoemulsion containing 4% benzyl alcohol evidenced a permeation rate higher than was observed with the 1% and 2% nanoemulsions. Also the nanoemulsion containing 1% Solutol(R) HS 15 provided a permeation rate higher than was seen with the 2% and 4% nanoemulsions. All ketoprofen-loaded nanoemulsions enhanced the in vitro permeation rate through mouse skins as compared to the control.

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Year:  2008        PMID： 18712624     DOI： 10.1080/10717540802328599

Source DB:  PubMed          Journal:  Drug Deliv        ISSN： 1071-7544            Impact factor:   6.419


  6 in total

Review 1.  Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems.

Authors:  Ahlam Zaid Alkilani; Jehad Nasereddin; Rania Hamed; Sukaina Nimrawi; Ghaid Hussein; Hadeel Abo-Zour; Ryan F Donnelly
Journal:  Pharmaceutics       Date:  2022-05-28       Impact factor: 6.525

2.  Nanocarrier for the transdermal delivery of an antiparkinsonian drug.

Authors:  Adnan Azeem; Farhan J Ahmad; Roop K Khar; Sushama Talegaonkar
Journal:  AAPS PharmSciTech       Date:  2009-09-09       Impact factor: 3.246

Review 3.  Application of liposomes in treatment of rheumatoid arthritis: quo vadis.

Authors:  Bhupinder Kapoor; Sachin Kumar Singh; Monica Gulati; Reena Gupta; Yogyata Vaidya
Journal:  ScientificWorldJournal       Date:  2014-02-04

Review 4.  Topical Nano and Microemulsions for Skin Delivery.

Authors:  Christofori M R R Nastiti; Thellie Ponto; Eman Abd; Jeffrey E Grice; Heather A E Benson; Michael S Roberts
Journal:  Pharmaceutics       Date:  2017-09-21       Impact factor: 6.321

5.  Size-dependent penetration of nanoemulsions into epidermis and hair follicles: implications for transdermal delivery and immunization.

Authors:  Rui Su; Wufa Fan; Qin Yu; Xiaochun Dong; Jianping Qi; Quangang Zhu; Weili Zhao; Wei Wu; Zhongjian Chen; Ye Li; Yi Lu
Journal:  Oncotarget       Date:  2017-06-13

6.  Effect of microemulsions on transdermal delivery of citalopram: optimization studies using mixture design and response surface methodology.

Authors:  Chi-Te Huang; Ming-Jun Tsai; Yu-Hsuan Lin; Yaw-Sya Fu; Yaw-Bin Huang; Yi-Hung Tsai; Pao-Chu Wu
Journal:  Int J Nanomedicine       Date:  2013-06-25
  6 in total

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