| Literature DB >> 18711366 |
Hiroyuki Unoki1, Atsushi Takahashi, Takahisa Kawaguchi, Kazuo Hara, Momoko Horikoshi, Gitte Andersen, Daniel P K Ng, Johan Holmkvist, Knut Borch-Johnsen, Torben Jørgensen, Annelli Sandbaek, Torsten Lauritzen, Torben Hansen, Siti Nurbaya, Tatsuhiko Tsunoda, Michiaki Kubo, Tetsuya Babazono, Hiroshi Hirose, Matsuhiko Hayashi, Yasuhiko Iwamoto, Atsunori Kashiwagi, Kohei Kaku, Ryuzo Kawamori, E Shyong Tai, Oluf Pedersen, Naoyuki Kamatani, Takashi Kadowaki, Ryuichi Kikkawa, Yusuke Nakamura, Shiro Maeda.
Abstract
We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 x 10(-12); OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 x 10(-9); OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 x 10(-13); OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36).Entities:
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Year: 2008 PMID： 18711366 DOI： 10.1038/ng.208
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330