| Literature DB >> 18706812 |
Ken Jacobson1, Zenon Rajfur, Eric Vitriol, Klaus Hahn.
Abstract
Chromophore-assisted laser inactivation (CALI) is a technique whereby engineered proteins and dye molecules that produce substantial amounts of reactive oxygen species upon absorption of light are used to perturb biological systems in a spatially and temporally defined manner. CALI is an important complement to conventional genetic and pharmacological manipulations. In this review, we examine the applications of CALI to cell biology and discuss the underlying photochemical mechanisms that mediate this powerful technique.Entities:
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Year: 2008 PMID: 18706812 PMCID: PMC4445427 DOI: 10.1016/j.tcb.2008.07.001
Source DB: PubMed Journal: Trends Cell Biol ISSN: 0962-8924 Impact factor: 20.808