Literature DB >> 18706811

Decoding the quantitative nature of TGF-beta/Smad signaling.

David C Clarke1, Xuedong Liu.   

Abstract

How transforming growth factor-beta (TGF-beta) signaling elicits diverse cell responses remains elusive, despite the major molecular components of the pathway being known. We contend that understanding TGF-beta biology requires mathematical models to decipher the quantitative nature of TGF-beta/Smad signaling and to account for its complexity. Here, we review mathematical models of TGF-beta superfamily signaling that predict how robustness is achieved in bone-morphogenetic-protein signaling in the Drosophila embryo, how changes in receptor-trafficking dynamics can be exploited by cancer cells and how the basic mechanisms of TGF-beta/Smad signaling conspire to promote Smad accumulation in the nucleus. These studies demonstrate the power of mathematical modeling for understanding TGF-beta biology.

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Year:  2008        PMID： 18706811      PMCID： PMC2774497          DOI： 10.1016/j.tcb.2008.06.006

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  78 in total

Review 1.  Variability and robustness in biomolecular systems.

Authors:  Naama Barkai; Ben-Zion Shilo
Journal:  Mol Cell       Date:  2007-12-14       Impact factor: 17.970

2.  SnapShot: The TGFbeta pathway interactome.

Authors:  Ian W Taylor; Jeffrey L Wrana
Journal:  Cell       Date:  2008-04-18       Impact factor: 41.582

3.  Nuclear accumulation of Smad complexes occurs only after the midblastula transition in Xenopus.

Authors:  Yasushi Saka; Anja I Hagemann; Olaf Piepenburg; James C Smith
Journal:  Development       Date:  2007-10-24       Impact factor: 6.868

Review 4.  TGF-beta signaling: a tale of two responses.

Authors:  Rod A Rahimi; Edward B Leof
Journal:  J Cell Biochem       Date:  2007-10-15       Impact factor: 4.429

Review 5.  The Decapentaplegic morphogen gradient: from pattern formation to growth regulation.

Authors:  Markus Affolter; Konrad Basler
Journal:  Nat Rev Genet       Date:  2007-09       Impact factor: 53.242

6.  Cross-talk between the bone morphogenetic protein pathway and other major signaling pathways results in tightly regulated cell-specific outcomes.

Authors:  Amaury Herpin; Charles Cunningham
Journal:  FEBS J       Date:  2007-05-22       Impact factor: 5.542

7.  Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.

Authors:  Jay Groppe; Cynthia S Hinck; Payman Samavarchi-Tehrani; Chloe Zubieta; Jonathan P Schuermann; Alexander B Taylor; Patricia M Schwarz; Jeffrey L Wrana; Andrew P Hinck
Journal:  Mol Cell       Date:  2008-02-01       Impact factor: 17.970

Review 8.  Theoretical and experimental approaches to understand morphogen gradients.

Authors:  Marta Ibañes; Juan Carlos Izpisúa Belmonte
Journal:  Mol Syst Biol       Date:  2008-03-25       Impact factor: 11.429

9.  Constraint-based modeling and kinetic analysis of the Smad dependent TGF-beta signaling pathway.

Authors:  Zhike Zi; Edda Klipp
Journal:  PLoS One       Date:  2007-09-26       Impact factor: 3.240

10.  Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads.

Authors:  Lan Xu; Xiaohao Yao; Xiaochu Chen; Peiyuan Lu; Biliang Zhang; Y Tony Ip
Journal:  J Cell Biol       Date:  2007-09-04       Impact factor: 10.539
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  40 in total

Review 1.  Roles of E3 ubiquitin ligases in cell adhesion and migration.

Authors:  Cai Huang
Journal:  Cell Adh Migr       Date:  2010-01-18       Impact factor: 3.405

2.  Spatial aspects in the SMAD signaling pathway.

Authors:  J Claus; E Friedmann; U Klingmüller; R Rannacher; T Szekeres
Journal:  J Math Biol       Date:  2012-09-18       Impact factor: 2.259

3.  Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling.

Authors:  Liyong Zhang; Takeo Fujita; George Wu; Xiao Xiao; Yong Wan
Journal:  J Biol Chem       Date:  2011-01-05       Impact factor: 5.157

4.  A mathematical model of the enhancement of tumor vaccine efficacy by immunotherapy.

Authors:  Shelby Wilson; Doron Levy
Journal:  Bull Math Biol       Date:  2012-03-22       Impact factor: 1.758

Review 5.  Regulation of BMP activity and range in Drosophila wing development.

Authors:  Laurel A Raftery; David M Umulis
Journal:  Curr Opin Cell Biol       Date:  2011-12-05       Impact factor: 8.382

6.  Live-cell single-molecule imaging reveals clathrin and caveolin-1 dependent docking of SMAD4 at the cell membrane.

Authors:  Yong Yang; Joy Wolfram; Jianliang Shen; Yuliang Zhao; Xiaohong Fang; Haifa Shen; Mauro Ferrari
Journal:  FEBS Lett       Date:  2013-11-06       Impact factor: 4.124

7.  A new multicompartmental reaction-diffusion modeling method links transient membrane attachment of E. coli MinE to E-ring formation.

Authors:  Satya Nanda Vel Arjunan; Masaru Tomita
Journal:  Syst Synth Biol       Date:  2009-12-10

8.  Transforming growth factor beta depletion is the primary determinant of Smad signaling kinetics.

Authors:  David C Clarke; Meredith L Brown; Richard A Erickson; Yigong Shi; Xuedong Liu
Journal:  Mol Cell Biol       Date:  2009-02-17       Impact factor: 4.272

Review 9.  Dynamics and precision in retinoic acid morphogen gradients.

Authors:  Thomas F Schilling; Qing Nie; Arthur D Lander
Journal:  Curr Opin Genet Dev       Date:  2012-12-19       Impact factor: 5.578

10.  A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response.

Authors:  Jenny Fung Ling Chau; Deyong Jia; Zhongfeng Wang; Zhi Liu; Yuanyu Hu; Xin Zhang; Hao Jia; Keng Po Lai; Wai Fook Leong; Bi Jin Au; Yuji Mishina; Ye-Guang Chen; Christine Biondi; Elizabeth Robertson; Dong Xie; Huijuan Liu; Lin He; Xueying Wang; Qiang Yu; Baojie Li
Journal:  Nat Commun       Date:  2012-05-15       Impact factor: 14.919
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