Literature DB >> 18700791

Tissue-specific expression and post-translational modification of histone H3 variants.

Benjamin A Garcia1, C Eric Thomas, Neil L Kelleher, Craig A Mizzen.   

Abstract

Analyses of histone H3 from 10 rat tissues using a Middle Down proteomics platform revealed tissue-specific differences in their expression and global PTM abundance. ESI/FTMS with electron capture dissociation showed that, in general, these proteins were hypomodified in heart, liver and testes. H3.3 was hypermodified compared to H3.2 in some, but not all tissues. In addition, a novel rat testes-specific H3 protein was identified with this approach.

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Year:  2008        PMID: 18700791      PMCID: PMC2615678          DOI: 10.1021/pr800044q

Source DB:  PubMed          Journal:  J Proteome Res        ISSN: 1535-3893            Impact factor:   4.466


  63 in total

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