Literature DB >> 18697993

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

Tomoko Wakabayashi1, Bart De Strooper.   

Abstract

The presenilins in combination with other proteins generate different gamma-secretases, which are involved in the regulated intramembrane proteolysis of a variety of proteins. Understanding the specificity and regulation of these proteases will potentially lead to novel therapeutics for Alzheimer's disease and cancer. Presenilins appear also to exert additional functions outside of the gamma-secretase quartets, which needs further investigation.

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Year:  2008        PMID： 18697993     DOI： 10.1152/physiol.00009.2008

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  56 in total

Review 1.  Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.

Authors:  Johannes Prox; Andrea Rittger; Paul Saftig
Journal:  Exp Brain Res       Date:  2011-11-27       Impact factor: 1.972

Review 2.  An overview of APP processing enzymes and products.

Authors:  Vivian W Chow; Mark P Mattson; Philip C Wong; Marc Gleichmann
Journal:  Neuromolecular Med       Date:  2010-03       Impact factor: 3.843

3.  And four equals one: presenilin takes the gamma-secretase role by itself.

Authors:  Christian B Lessard; Steven L Wagner; Edward H Koo
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-06       Impact factor: 11.205

4.  γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.

Authors:  Jyoti Chhibber-Goel; Caroline Coleman-Vaughan; Vishal Agrawal; Neha Sawhney; Emer Hickey; James C Powell; Justin V McCarthy
Journal:  J Biol Chem       Date:  2016-01-11       Impact factor: 5.157

5.  Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

Authors:  Enrico Zampese; Cristina Fasolato; Maulilio J Kipanyula; Mario Bortolozzi; Tullio Pozzan; Paola Pizzo
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-01       Impact factor: 11.205

Review 6.  Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.

Authors:  Bart De Strooper; Takeshi Iwatsubo; Michael S Wolfe
Journal:  Cold Spring Harb Perspect Med       Date:  2012-01       Impact factor: 6.915

7.  Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.

Authors:  Edith Winkler; Frits Kamp; Johannes Scheuring; Amelie Ebke; Akio Fukumori; Harald Steiner
Journal:  J Biol Chem       Date:  2012-04-24       Impact factor: 5.157

Review 8.  The genetics and neuropathology of Alzheimer's disease.

Authors:  Gerard D Schellenberg; Thomas J Montine
Journal:  Acta Neuropathol       Date:  2012-05-23       Impact factor: 17.088

9.  Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection.

Authors:  Nathan J Weyand; Christine M Calton; Dustin L Higashi; Kristen J Kanack; Magdalene So
Journal:  J Immunol       Date:  2009-12-16       Impact factor: 5.422

10.  Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.

Authors:  Estela Area-Gomez; Ad J C de Groof; Istvan Boldogh; Thomas D Bird; Gary E Gibson; Carla M Koehler; Wai Haung Yu; Karen E Duff; Michael P Yaffe; Liza A Pon; Eric A Schon
Journal:  Am J Pathol       Date:  2009-10-15       Impact factor: 4.307
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