Literature DB >> 18697953

Prevalence of copy-number neutral LOH in glioblastomas revealed by genomewide analysis of laser-microdissected tissues.

Daisuke Kuga1, Masahiro Mizoguchi, Yanlei Guan, Nobuhiro Hata, Koji Yoshimoto, Tadahisa Shono, Satoshi O Suzuki, Yoji Kukita, Tomoko Tahira, Shinji Nagata, Tomio Sasaki, Kenshi Hayashi.   

Abstract

We have employed a laser-capture microdissection technique and single-nucleotide polymorphism arrays to characterize genomic alterations associated with the development of glioblastoma multiforme (GBM). Combined analysis of loss of heterozygosity (LOH) and copy number revealed that more than half (56.3%) of the 254 identified LOH loci showed no copy-number alteration, indicating the presence of copy-number neutral LOH (cnLOH). Furthermore, we found a GBM case that showed cnLOH in 18 of the 22 autosomes. These results were confirmed by quantitative real-time PCR, microsatellite analysis, and fluorescence in situ hybridization. The high rate of cnLOH suggests that epigenetic abnormalities of many genes are involved in the development and progression of GBMs.

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Year:  2008        PMID： 18697953      PMCID： PMC2719013          DOI： 10.1215/15228517-2008-064

Source DB:  PubMed          Journal:  Neuro Oncol        ISSN： 1522-8517            Impact factor:   12.300


  28 in total

1.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

Authors:  K J Livak; T D Schmittgen
Journal:  Methods       Date:  2001-12       Impact factor: 3.608

2.  Digital karyotyping.

Authors:  Tian-Li Wang; Christine Maierhofer; Michael R Speicher; Christoph Lengauer; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-02       Impact factor: 11.205

3.  An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays.

Authors:  Xiaojun Zhao; Cheng Li; J Guillermo Paez; Koei Chin; Pasi A Jänne; Tzu-Hsiu Chen; Luc Girard; John Minna; David Christiani; Chris Leo; Joe W Gray; William R Sellers; Matthew Meyerson
Journal:  Cancer Res       Date:  2004-05-01       Impact factor: 12.701

4.  dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data.

Authors:  Ming Lin; Lee-Jen Wei; William R Sellers; Marshall Lieberfarb; Wing Hung Wong; Cheng Li
Journal:  Bioinformatics       Date:  2004-02-10       Impact factor: 6.937

Review 5.  Altered molecular pathways in gliomas: an overview of clinically relevant issues.

Authors:  Ravi D Rao; C David James
Journal:  Semin Oncol       Date:  2004-10       Impact factor: 4.929

6.  Mitotic recombination of chromosome 17 in astrocytomas.

Authors:  C D James; E Carlbom; M Nordenskjold; V P Collins; W K Cavenee
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

Review 7.  Signaling pathways regulating gliomagenesis.

Authors:  G Konopka; A Bonni
Journal:  Curr Mol Med       Date:  2003-02       Impact factor: 2.222

8.  Genetic pathways to glioblastoma: a population-based study.

Authors:  Hiroko Ohgaki; Pierre Dessen; Benjamin Jourde; Sonja Horstmann; Tomofumi Nishikawa; Pier-Luigi Di Patre; Christoph Burkhard; Danielle Schüler; Nicole M Probst-Hensch; Paulo César Maiorka; Nathalie Baeza; Paola Pisani; Yasuhiro Yonekawa; M Gazi Yasargil; Urs M Lütolf; Paul Kleihues
Journal:  Cancer Res       Date:  2004-10-01       Impact factor: 12.701

9.  Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10.

Authors:  A E Karlbom; C D James; J Boethius; W K Cavenee; V P Collins; M Nordenskjöld; C Larsson
Journal:  Hum Genet       Date:  1993-09       Impact factor: 4.132

10.  Multiplexed analysis of post-PCR fluorescence-labeled microsatellite alleles and statistical evaluation of their imbalance in brain tumors.

Authors:  Koji Yoshimoto; Toru Iwaki; Takanori Inamura; Masashi Fukui; Tomoko Tahira; Kenshi Hayashi
Journal:  Jpn J Cancer Res       Date:  2002-03
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  14 in total

1.  Parent-specific copy number in paired tumor-normal studies using circular binary segmentation.

Authors:  Adam B Olshen; Henrik Bengtsson; Pierre Neuvial; Paul T Spellman; Richard A Olshen; Venkatraman E Seshan
Journal:  Bioinformatics       Date:  2011-06-11       Impact factor: 6.937

2.  Differences in genetic and epigenetic alterations between von Hippel-Lindau disease-related and sporadic hemangioblastomas of the central nervous system.

Authors:  Shunsaku Takayanagi; Akitake Mukasa; Shota Tanaka; Masashi Nomura; Mayu Omata; Shunsuke Yanagisawa; Shogo Yamamoto; Koichi Ichimura; Hirofumi Nakatomi; Keisuke Ueki; Hiroyuki Aburatani; Nobuhito Saito
Journal:  Neuro Oncol       Date:  2017-09-01       Impact factor: 12.300

3.  Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells.

Authors:  Mohd Firdaus Che Mat; Ezanee Azlina Mohamad Hanif; Nor Azian Abdul Murad; Kamariah Ibrahim; Roslan Harun; Rahman Jamal
Journal:  Mol Biol Rep       Date:  2021-02-15       Impact factor: 2.316

4.  Association between acquired uniparental disomy and homozygous mutations and HER2/ER/PR status in breast cancer.

Authors:  Musaffe Tuna; Marcel Smid; Dakai Zhu; John W M Martens; Christopher I Amos
Journal:  PLoS One       Date:  2010-11-30       Impact factor: 3.240

5.  Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL.

Authors:  Simone Zaccaria; Benjamin J Raphael
Journal:  Nat Biotechnol       Date:  2020-09-02       Impact factor: 54.908

Review 6.  Cell biology of glioblastoma multiforme: from basic science to diagnosis and treatment.

Authors:  George S Stoyanov; Deyan Dzhenkov; Peter Ghenev; Bogomil Iliev; Yavor Enchev; Anton B Tonchev
Journal:  Med Oncol       Date:  2018-01-31       Impact factor: 3.064

7.  Chromosome 17p Homodisomy Is Associated With Better Outcome in 1p19q Non-Codeleted and IDH-Mutated Gliomas.

Authors:  Marianne Labussière; Amithys Rahimian; Marine Giry; Blandine Boisselier; Yohann Schmitt; Marc Polivka; Karima Mokhtari; Jean-Yves Delattre; Ahmed Idbaih; Karim Labreche; Agusti Alentorn; Marc Sanson
Journal:  Oncologist       Date:  2016-07-08       Impact factor: 5.837

8.  Genome wide analysis of DNA copy number neutral loss of heterozygosity (CNNLOH) and its relation to gene expression in esophageal squamous cell carcinoma.

Authors:  Nan Hu; Robert J Clifford; Howard H Yang; Chaoyu Wang; Alisa M Goldstein; Ti Ding; Philip R Taylor; Maxwell P Lee
Journal:  BMC Genomics       Date:  2010-10-18       Impact factor: 3.969

9.  Distinct genomic aberrations between low-grade and high-grade gliomas of Chinese patients.

Authors:  Yunbo Li; Dapeng Wang; Lei Wang; Jinhai Yu; Danhua Du; Ye Chen; Peng Gao; Duen-Mei Wang; Jun Yu; Feng Zhang; Shuanglin Fu
Journal:  PLoS One       Date:  2013-02-22       Impact factor: 3.240

10.  Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy.

Authors:  Musaffe Tuna; Zhenlin Ju; Christopher I Amos; Gordon B Mills
Journal:  BMC Med Genomics       Date:  2012-12-05       Impact factor: 3.063
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