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Literature DB >> 18695502

Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats.

Koichi Iwatsuki¹, Toshiki Yoshimine, Haruhiko Kishima, Masanori Aoki, Kazuhiro Yoshimura, Masahiro Ishihara, Yuichiro Ohnishi, Carlos Lima.

Abstract

Several recent studies have demonstrated the potential therapeutic role of olfactory ensheathing cells in spinal cord injury. The aim of this study was to elucidate whether grafts of nasal olfactory mucosa containing olfactory ensheathing cells can repair the injured rat spinal cord as compared with the nasal respiratory mucosa containing no olfactory ensheathing cells. These grafts were then transplanted into the partially removed rat spinal cord. Compared with the respiratory mucosa-transplanted rats, the olfactory mucosa-transplanted rats partially recovered the movement of their hindlimbs and joints. Corticospinal tracing indicated that olfactory mucosa transplantation restored the severed tract. Therefore, olfactory mucosa has potential value in the repair of spinal cord injury.

Entities: Disease Species

Mesh：

Year: 2008 PMID： 18695502 DOI： 10.1097/WNR.0b013e328305b70b

Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837

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Cited

15 in total

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6. Motor evoked potential and voluntary EMG activity after olfactory mucosal autograft transplantation in a case of chronic, complete spinal cord injury: case report.

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7. Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation.

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