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Literature DB >> 18694944

Metronidazole lacks antibacterial activity in guinea pigs infected with Mycobacterium tuberculosis.

Donald R Hoff¹, Megan L Caraway, Elizabeth J Brooks, Emily R Driver, Gavin J Ryan, Charles A Peloquin, Ian M Orme, Randall J Basaraba, Anne J Lenaerts.

Abstract

Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.

Entities: Chemical Disease Species

Mesh：

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Year: 2008 PMID： 18694944 PMCID： PMC2573095 DOI： 10.1128/AAC.00196-08

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

1. Metronidazole therapy in mice infected with tuberculosis.

Authors: J V Brooks; S K Furney; I M Orme
Journal: Antimicrob Agents Chemother Date: 1999-05 Impact factor: 5.191

Review 2. New insights into the function of granulomas in human tuberculosis.

Authors: Timo Ulrichs; Stefan H E Kaufmann
Journal: J Pathol Date: 2006-01 Impact factor: 7.996

3. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence.

Authors: L G Wayne; L G Hayes
Journal: Infect Immun Date: 1996-06 Impact factor: 3.441

4. Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.

Authors: Christine M Johnson; Rajesh Pandey; Sadhna Sharma; G K Khuller; Randall J Basaraba; Ian M Orme; Anne J Lenaerts
Journal: Antimicrob Agents Chemother Date: 2005-10 Impact factor: 5.191

5. Modified immunohistological staining allows detection of Ziehl-Neelsen-negative Mycobacterium tuberculosis organisms and their precise localization in human tissue.

Authors: Timo Ulrichs; Michael Lefmann; Maja Reich; Lars Morawietz; Andreas Roth; Volker Brinkmann; George A Kosmiadi; Peter Seiler; Peter Aichele; Helmut Hahn; Veit Krenn; Ulf B Göbel; Stefan H E Kaufmann
Journal: J Pathol Date: 2005-04 Impact factor: 7.996

6. Action of metronidazole in combination with isoniazid & rifampicin on persisting organisms in experimental murine tuberculosis.

Authors: C N Paramasivan; G Kubendiran; D Herbert
Journal: Indian J Med Res Date: 1998-10 Impact factor: 2.375

7. Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis.

Authors: Oliver C Turner; Randall J Basaraba; Ian M Orme
Journal: Infect Immun Date: 2003-02 Impact factor: 3.441

8. Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis.

Authors: L G Wayne; H A Sramek
Journal: Antimicrob Agents Chemother Date: 1994-09 Impact factor: 5.191

9. Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.

Authors: Anne J Lenaerts; Donald Hoff; Sahar Aly; Stefan Ehlers; Koen Andries; Luis Cantarero; Ian M Orme; Randall J Basaraba
Journal: Antimicrob Agents Chemother Date: 2007-05-21 Impact factor: 5.191

10. Metronidazole has no antibacterial effect in Cornell model murine tuberculosis.

Authors: J Dhillon; B W Allen; Y M Hu; A R Coates; D A Mitchison
Journal: Int J Tuberc Lung Dis Date: 1998-09 Impact factor: 2.373

19 in total

1. Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections.

Authors: Zahoor Ahmad; Mostafa M Fraig; Gregory P Bisson; Eric L Nuermberger; Jacques H Grosset; Petros C Karakousis
Journal: Antimicrob Agents Chemother Date: 2011-01-31 Impact factor: 5.191

2. Metronidazole validates drugs targeting hypoxic bacteria for improved treatment of tuberculosis.

Authors: Ying Zhang
Journal: Proc Natl Acad Sci U S A Date: 2012-08-15 Impact factor: 11.205

Review 3. Development of new vaccines and drugs for TB: limitations and potential strategic errors.

Authors: Ian M Orme
Journal: Future Microbiol Date: 2011-02 Impact factor: 3.165

4. Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis.

Authors: Emily R Driver; Gavin J Ryan; Donald R Hoff; Scott M Irwin; Randall J Basaraba; Igor Kramnik; Anne J Lenaerts
Journal: Antimicrob Agents Chemother Date: 2012-04-02 Impact factor: 5.191

Review 5. Modelling a Silent Epidemic: A Review of the In Vitro Models of Latent Tuberculosis.

Authors: Savannah E R Gibson; James Harrison; Jonathan A G Cox
Journal: Pathogens Date: 2018-11-15

6. Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques.

Authors: Philana Ling Lin; Veronique Dartois; Paul J Johnston; Christopher Janssen; Laura Via; Michael B Goodwin; Edwin Klein; Clifton E Barry; Joanne L Flynn
Journal: Proc Natl Acad Sci U S A Date: 2012-07-23 Impact factor: 11.205

7. Reduction of clofazimine by mycobacterial type 2 NADH:quinone oxidoreductase: a pathway for the generation of bactericidal levels of reactive oxygen species.

Authors: Takahiro Yano; Sacha Kassovska-Bratinova; J Shin Teh; Jeffrey Winkler; Kevin Sullivan; Andre Isaacs; Norman M Schechter; Harvey Rubin
Journal: J Biol Chem Date: 2010-12-30 Impact factor: 5.157