BACKGROUND: Estrogen-progestin contraception may affect estrogen production and alter the development of peak bone mass. STUDY DESIGN: A 4-year follow-up with 122 adolescent women aged 12-19 years. The data were divided into three groups based on estrogen-progestin contraceptive (EPC) use: (i) nonusers (n=52), (ii) 1-2 years of use (n=24) and (iii) use for more than 2 years (n=46). The estrogen dose of the preparations was < or =35 mcg. Height, weight, and the amount of exercise (ratio of work metabolic rate, h/week) as well as bone mineral content (BMC) of lumbar spine and femoral neck were measured repeatedly. RESULTS: There was a significant trend showing less of an increase in the mean adjusted BMC of lumbar spine in the group of adolescent women who had used EPC for more than 2 years compared with the two other groups. In the mean adjusted BMC of the femoral neck, there was a significant trend of a smaller increase in EPC users for more than 2 years compared with 1-2 years of use. CONCLUSIONS: Long-term EPC with low-dose estrogen preparations seems to suppress normal bone mineral accrual in adolescent women.
BACKGROUND: Estrogen-progestin contraception may affect estrogen production and alter the development of peak bone mass. STUDY DESIGN: A 4-year follow-up with 122 adolescent women aged 12-19 years. The data were divided into three groups based on estrogen-progestin contraceptive (EPC) use: (i) nonusers (n=52), (ii) 1-2 years of use (n=24) and (iii) use for more than 2 years (n=46). The estrogen dose of the preparations was < or =35 mcg. Height, weight, and the amount of exercise (ratio of work metabolic rate, h/week) as well as bone mineral content (BMC) of lumbar spine and femoral neck were measured repeatedly. RESULTS: There was a significant trend showing less of an increase in the mean adjusted BMC of lumbar spine in the group of adolescent women who had used EPC for more than 2 years compared with the two other groups. In the mean adjusted BMC of the femoral neck, there was a significant trend of a smaller increase in EPC users for more than 2 years compared with 1-2 years of use. CONCLUSIONS: Long-term EPC with low-dose estrogen preparations seems to suppress normal bone mineral accrual in adolescent women.
Authors: Delia Scholes; Rebecca A Hubbard; Laura E Ichikawa; Andrea Z LaCroix; Leslie Spangler; Jeannette M Beasley; Susan Reed; Susan M Ott Journal: J Clin Endocrinol Metab Date: 2011-07-13 Impact factor: 5.958
Authors: C M Weaver; C M Gordon; K F Janz; H J Kalkwarf; J M Lappe; R Lewis; M O'Karma; T C Wallace; B S Zemel Journal: Osteoporos Int Date: 2016-02-08 Impact factor: 4.507
Authors: Delia Scholes; Laura Ichikawa; Andrea Z LaCroix; Leslie Spangler; Jeannette M Beasley; Susan Reed; Susan M Ott Journal: Contraception Date: 2010-01 Impact factor: 3.375
Authors: Hawley C Almstedt; Makenzie M Cook; Lily F Bramble; Deepa V Dabir; Joseph W LaBrie Journal: J Bone Miner Metab Date: 2020-01-25 Impact factor: 2.626
Authors: Tatjana S Brajic; Claudie Berger; Katharina Schlammerl; Heather Macdonald; Shirin Kalyan; David A Hanley; Jonathan D Adachi; Christopher S Kovacs; Jerilynn C Prior Journal: J Musculoskelet Neuronal Interact Date: 2018-06-01 Impact factor: 2.041