Literature DB >> 18692601

XPD structure reveals its secrets.

Alan R Lehmann1.   

Abstract

The XPD protein is central to our understanding of the relationship between NER deficiencies and human disorders. Three recent papers report the crystal structures of XPD from archaea. Apart from anticipated helicase domains the structures reveal a 4FeS cluster and novel "Arch" domain. The structures help our understanding of genotype-phenotype relationships in the XPD gene.

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Year:  2008        PMID： 18692601     DOI： 10.1016/j.dnarep.2008.07.008

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  16 in total

1.  Subunit architecture of general transcription factor TFIIH.

Authors:  Brian J Gibbons; Edward J Brignole; Maia Azubel; Kenji Murakami; Neil R Voss; David A Bushnell; Francisco J Asturias; Roger D Kornberg
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-20       Impact factor: 11.205

2.  DNA charge transport as a first step in coordinating the detection of lesions by repair proteins.

Authors:  Pamela A Sontz; Timothy P Mui; Jill O Fuss; John A Tainer; Jacqueline K Barton
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-23       Impact factor: 11.205

3.  Single-stranded DNA binding activity of XPBI, but not XPBII, from Sulfolobus tokodaii causes double-stranded DNA melting.

Authors:  Xiaoqing Ma; Ye Hong; Wenyuan Han; Duohong Sheng; Jinfeng Ni; Guihua Hou; Yulong Shen
Journal:  Extremophiles       Date:  2010-12-05       Impact factor: 2.395

4.  Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase.

Authors:  Nadine Mathieu; Nina Kaczmarek; Hanspeter Naegeli
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-27       Impact factor: 11.205

5.  XPD Lys751Gln increases the risk of breast cancer.

Authors:  Mani Samson; Shirley Sunder Singh; Ranganathan Rama; Veluswami Sridevi; Thangarajan Rajkumar
Journal:  Oncol Lett       Date:  2010-11-23       Impact factor: 2.967

6.  DNA helicases associated with genetic instability, cancer, and aging.

Authors:  Avvaru N Suhasini; Robert M Brosh
Journal:  Adv Exp Med Biol       Date:  2013       Impact factor: 2.622

Review 7.  Mechanistic and biological aspects of helicase action on damaged DNA.

Authors:  Avvaru N Suhasini; Robert M Brosh
Journal:  Cell Cycle       Date:  2010-06-15       Impact factor: 4.534

Review 8.  Photosensitive human syndromes.

Authors:  Graciela Spivak; Philip C Hanawalt
Journal:  Mutat Res       Date:  2014-11-14       Impact factor: 2.433

9.  Meta-analysis on the association of nucleotide excision repair gene XPD A751C variant and cancer susceptibility among Indian population.

Authors:  Raju Kumar Mandal; Suraj Singh Yadav; Aditya K Panda
Journal:  Mol Biol Rep       Date:  2013-12-22       Impact factor: 2.316

10.  The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway.

Authors:  Jana Rudolf; Christophe Rouillon; Ulrich Schwarz-Linek; Malcolm F White
Journal:  Nucleic Acids Res       Date:  2009-11-20       Impact factor: 16.971
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