| Literature DB >> 18692464 |
Ming O Li1, Richard A Flavell.
Abstract
A functional adaptive immune system depends on a diverse and self-tolerant population of T lymphocytes that are generated in the thymus and maintained in the peripheral lymphoid organs. Recent studies have defined the cytokine transforming growth factor-beta (TGF-beta) as a critical regulator of thymic T cell development as well as a crucial player in peripheral T cell homeostasis, tolerance to self antigens, and T cell differentiation during the immune response. The unique mechanism of TGF-beta activation and the plasticity of TGF-beta signaling create a stage for TGF-beta to integrate signals from multiple cell types and environmental cues to regulate T cells.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18692464 PMCID： PMC3677783 DOI： 10.1016/j.cell.2008.07.025
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582