OBJECTIVES: To compare the time-course of cytokine levels in patients with and without delirium and investigate differences in cytokine concentrations in delirium subtypes. DESIGN: Prospective cohort study. SETTING: Academic Medical Center, Amsterdam, 2005 through 2007. PARTICIPANTS: Patients aged 65 and older admitted for surgery after hip fracture. MEASUREMENTS: Experienced geriatric physicians used the Confusion Assessment Method to assess delirium and the Delirium Symptom Interview to assess delirium subtype. Tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1beta, IL-6, IL-8, IL-10, and IL-12 were assayed in repeated serum samples using a cytometric bead array immunoassay. RESULTS: Of 221 admitted patients, 98 (mean age 84, 50 patients with delirium) were included, resulting in a total of 324 samples. Ninety-six percent of these samples had TNF-alpha, IL-1beta, and IL-10 levels below the reliable detection level. Differences between patients with and without delirium were observed in IL-6 (median 51 vs 36 pg/mL, P=.01) and IL-8 (median 15 vs 9 pg/mL, P=.03) levels. Changes over time in IL-6 and IL-8 levels in patients with delirium differed significantly from changes in levels in patients without delirium. The highest levels of IL-6 were present during delirium, and the highest levels of IL-8 were present before the development of delirium. Patients with the hyperactive (median 71 pg/mL) or mixed (median 73 pg/mL) subtype of delirium had higher IL-6 levels than patients with hypoactive delirium (median 16 pg/mL) (P=.02). CONCLUSION: IL-6 and IL-8 may contribute to the pathogenesis of postoperative delirium in elderly people. IL-6 may play a role in the hyperactive behavior of delirium.
OBJECTIVES: To compare the time-course of cytokine levels in patients with and without delirium and investigate differences in cytokine concentrations in delirium subtypes. DESIGN: Prospective cohort study. SETTING: Academic Medical Center, Amsterdam, 2005 through 2007. PARTICIPANTS: Patients aged 65 and older admitted for surgery after hip fracture. MEASUREMENTS: Experienced geriatric physicians used the Confusion Assessment Method to assess delirium and the Delirium Symptom Interview to assess delirium subtype. Tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1beta, IL-6, IL-8, IL-10, and IL-12 were assayed in repeated serum samples using a cytometric bead array immunoassay. RESULTS: Of 221 admitted patients, 98 (mean age 84, 50 patients with delirium) were included, resulting in a total of 324 samples. Ninety-six percent of these samples had TNF-alpha, IL-1beta, and IL-10 levels below the reliable detection level. Differences between patients with and without delirium were observed in IL-6 (median 51 vs 36 pg/mL, P=.01) and IL-8 (median 15 vs 9 pg/mL, P=.03) levels. Changes over time in IL-6 and IL-8 levels in patients with delirium differed significantly from changes in levels in patients without delirium. The highest levels of IL-6 were present during delirium, and the highest levels of IL-8 were present before the development of delirium. Patients with the hyperactive (median 71 pg/mL) or mixed (median 73 pg/mL) subtype of delirium had higher IL-6 levels than patients with hypoactive delirium (median 16 pg/mL) (P=.02). CONCLUSION:IL-6 and IL-8 may contribute to the pathogenesis of postoperative delirium in elderly people. IL-6 may play a role in the hyperactive behavior of delirium.
Authors: Sarinnapha M Vasunilashorn; Long Ngo; Sharon K Inouye; Towia A Libermann; Richard N Jones; David C Alsop; Jamey Guess; Sandra Jastrzebski; Janet E McElhaney; George A Kuchel; Edward R Marcantonio Journal: J Gerontol A Biol Sci Med Sci Date: 2015-07-27 Impact factor: 6.053
Authors: Ayòtúndé B Fadayomi; Reine Ibala; Federico Bilotta; Michael B Westover; Oluwaseun Akeju Journal: Crit Care Med Date: 2018-12 Impact factor: 7.598
Authors: Annemarieke de Jonghe; Barbara C van Munster; Hannah E van Oosten; J Carel Goslings; Peter Kloen; Carolien van Rees; Reinder Wolvius; Romuald van Velde; Marcel M Levi; Joke C Korevaar; Sophia E de Rooij Journal: BMC Geriatr Date: 2011-07-05 Impact factor: 3.921
Authors: Subash C Gupta; Ji Hye Kim; Ramaswamy Kannappan; Simone Reuter; Patrick M Dougherty; Bharat B Aggarwal Journal: Exp Biol Med (Maywood) Date: 2011-05-12
Authors: Annemarieke de Jonghe; Barbara C van Munster; J Carel Goslings; Peter Kloen; Carolien van Rees; Reinder Wolvius; Romuald van Velde; Marcel Levi; Rob J de Haan; Sophia E de Rooij Journal: CMAJ Date: 2014-09-02 Impact factor: 8.262
Authors: Alex Bekker; Michael Haile; Richard Kline; Sorosch Didehvar; Ramesh Babu; Frank Martiniuk; Michael Urban Journal: J Neurosurg Anesthesiol Date: 2013-01 Impact factor: 3.956
Authors: Timothy D Girard; Lorraine B Ware; Gordon R Bernard; Pratik P Pandharipande; Jennifer L Thompson; Ayumi K Shintani; James C Jackson; Robert S Dittus; E Wesley Ely Journal: Intensive Care Med Date: 2012-08-18 Impact factor: 17.440