Literature DB >> 18690791

Wnt-signaling in retinal development and disease.

Eleonora M Lad1, Samuel H Cheshier, M Yashar S Kalani.   

Abstract

The Wnt-signaling pathway is a known regulator of stem cell maintenance, cellular proliferation and differentiation, and cancer development in various tissues. Wnt proteins play a central role during various stages of retinal development; retinal field establishment, retinal and hyaloid vasculogenesis, cornea and lens development, eye field formation, and maintenance of retinal stem cell and neuronal specification in many species are Wnt-regulated processes. Uncontrolled Wnt signaling may cause retinal diseases such as familial exudative vitroretinopathy, retinitis pigmentosa, and Norrie's disease, further underscoring the importance of the Wnt-signaling pathway in the retina. This review summarizes major developments and discoveries regarding the role of the Wnt-signaling pathway as it pertains to retinal development and disease.

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Year:  2009        PMID： 18690791     DOI： 10.1089/scd.2008.0169

Source DB:  PubMed          Journal:  Stem Cells Dev        ISSN： 1547-3287            Impact factor:   3.272


  22 in total

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Review 4.  What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.

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5.  Anti-angiogenic Therapy for Retinal Disease.

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Review 7.  Ciliary signaling cascades in photoreceptors.

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Review 9.  The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina.

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10.  Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development.

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Journal:  Cell Rep       Date:  2022-02-01       Impact factor: 9.423
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