Literature DB >> 18688856

Multiple pathways for Epstein-Barr virus episome loss from nasopharyngeal carcinoma.

Dirk P Dittmer1, Chelsey J Hilscher, Margaret L Gulley, Eric V Yang, Min Chen, Ronald Glaser.   

Abstract

Epstein-Barr virus (EBV) is the prototypical example for episomal persistence of genetic information. Yet, little is known about how this viral episome is lost. Episome loss occurs naturally in nasopharyngeal carcinoma (NPC) upon explantation into culture. Using whole-genome profiling, we found evidence for 2 different pathways of episome loss: (i) rapid loss of the entire episome or (ii) successive mutation/deletion of the episome until at least 1 essential cis-element is destroyed. This second phenotype was seen in a clone of HONE-1 NPC cells that maintains the EBV episome for prolonged time in culture. The conceptual insights provided by our quantitative analysis should aid our understanding of mammalian episomes, as well as lead to designs to cure latent viral infection. (c) 2008 Wiley-Liss, Inc.

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Year:  2008        PMID： 18688856      PMCID： PMC2866115          DOI： 10.1002/ijc.23685

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  42 in total

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5.  Epithelial cell retention of transcriptionally active, P3HR-1-derived heterogeneous Epstein-Barr virus DNA with concurrent loss of parental virus.

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6.  Comprehensive high-throughput RNA sequencing analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes.

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9.  Vaccination against a hit-and-run viral cancer.

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10.  Comparison of humoral immune responses to Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus using a viral proteome microarray.

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