Literature DB >> 18688346

G-quadruplex recognition by bis-indole carboxamides.

Jyotirmayee Dash1, Pravin S Shirude, Shankar Balasubramanian.   

Abstract

Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.

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Year:  2008        PMID： 18688346      PMCID： PMC2746961          DOI： 10.1039/b806042h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  35 in total

Review 1.  G-quadruplex DNA: a potential target for anti-cancer drug design.

Authors:  H Han; L H Hurley
Journal:  Trends Pharmacol Sci       Date:  2000-04       Impact factor: 14.819

Review 2.  Isolation and synthesis of biologically active carbazole alkaloids.

Authors:  Hans-Joachim Knölker; Kethiri R Reddy
Journal:  Chem Rev       Date:  2002-11       Impact factor: 60.622

Review 3.  The design of G-quadruplex ligands as telomerase inhibitors.

Authors:  Javier Cuesta; Martin A Read; Stephen Neidle
Journal:  Mini Rev Med Chem       Date:  2003-02       Impact factor: 3.862

4.  Thermodynamics and structure of a DNA tetraplex: a spectroscopic and calorimetric study of the tetramolecular complexes of d(TG3T) and d(TG3T2G3T).

Authors:  R Jin; B L Gaffney; C Wang; R A Jones; K J Breslauer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

Review 5.  Practical methodologies for the synthesis of indoles.

Authors:  Guy R Humphrey; Jeffrey T Kuethe
Journal:  Chem Rev       Date:  2006-07       Impact factor: 60.622

Review 6.  A hitchhiker's guide to G-quadruplex ligands.

Authors:  David Monchaud; Marie-Paule Teulade-Fichou
Journal:  Org Biomol Chem       Date:  2007-11-14       Impact factor: 3.876

7.  Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands.

Authors:  Gaëlle Pennarun; Christine Granotier; Laurent R Gauthier; Dennis Gomez; Françoise Hoffschir; Eliane Mandine; Jean-François Riou; Jean-Louis Mergny; Patrick Mailliet; François D Boussin
Journal:  Oncogene       Date:  2005-04-21       Impact factor: 9.867

8.  Putative DNA quadruplex formation within the human c-kit oncogene.

Authors:  Sarah Rankin; Anthony P Reszka; Julian Huppert; Mire Zloh; Gary N Parkinson; Alan K Todd; Sylvain Ladame; Shankar Balasubramanian; Stephen Neidle
Journal:  J Am Chem Soc       Date:  2005-08-03       Impact factor: 15.419

9.  Highly prevalent putative quadruplex sequence motifs in human DNA.

Authors:  Alan K Todd; Matthew Johnston; Stephen Neidle
Journal:  Nucleic Acids Res       Date:  2005-05-24       Impact factor: 16.971

10.  Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4.

Authors:  Yong Qin; Evonne M Rezler; Vijay Gokhale; Daekyu Sun; Laurence H Hurley
Journal:  Nucleic Acids Res       Date:  2007-11-05       Impact factor: 16.971
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  8 in total

1.  Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.

Authors:  Anthony Bugaut; Raphaël Rodriguez; Sunita Kumari; Shang-Te Danny Hsu; Shankar Balasubramanian
Journal:  Org Biomol Chem       Date:  2010-04-30       Impact factor: 3.876

2.  Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes.

Authors:  Rajendra Kumar; Karam Chand; Sudipta Bhowmik; Rabindra Nath Das; Snehasish Bhattacharjee; Mattias Hedenström; Erik Chorell
Journal:  Nucleic Acids Res       Date:  2020-02-20       Impact factor: 16.971

3.  Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.

Authors:  Peda V L Boddupally; Seongmin Hahn; Cristina Beman; Biswanath De; Tracy A Brooks; Vijay Gokhale; Laurence H Hurley
Journal:  J Med Chem       Date:  2012-06-25       Impact factor: 7.446

4.  G-quadruplex nucleic acids as therapeutic targets.

Authors:  Shankar Balasubramanian; Stephen Neidle
Journal:  Curr Opin Chem Biol       Date:  2009-06-08       Impact factor: 8.822

5.  Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction.

Authors:  Shalu Sharma; Ananda Kishore Mukherjee; Shuvra Shekhar Roy; Sulochana Bagri; Silje Lier; Meenakshi Verma; Antara Sengupta; Manish Kumar; Gaute Nesse; Deo Prakash Pandey; Shantanu Chowdhury
Journal:  Cell Rep       Date:  2021-05-18       Impact factor: 9.423

6.  Verification of specific G-quadruplex structure by using a novel cyanine dye supramolecular assembly: II. The binding characterization with specific intramolecular G-quadruplex and the recognizing mechanism.

Authors:  Qianfan Yang; Junfeng Xiang; Shu Yang; Qian Li; Qiuju Zhou; Aijiao Guan; Xiufeng Zhang; Hong Zhang; Yalin Tang; Guangzhi Xu
Journal:  Nucleic Acids Res       Date:  2009-11-19       Impact factor: 16.971

7.  Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes.

Authors:  Jyotirmayee Dash; Pravin S Shirude; Shang-Te Danny Hsu; Shankar Balasubramanian
Journal:  J Am Chem Soc       Date:  2008-11-26       Impact factor: 15.419

8.  Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease?

Authors:  Silvia Da Ros; Eleonora Zorzan; Mery Giantin; Lara Zorro Shahidian; Manlio Palumbo; Mauro Dacasto; Claudia Sissi
Journal:  PLoS One       Date:  2014-08-01       Impact factor: 3.240
  8 in total

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