BACKGROUND: Although deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson disease (PD) improves motor function, it has variable effects on working memory (WM) and response inhibition (RI) performance. The purpose of this study was to determine the neural correlates of STN DBS-induced variability in cognitive performance. METHODS: We measured bilateral STN DBS-induced blood flow changes (PET and [(15)O]-water on one day) in the supplementary motor area (SMA), dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), and right inferior frontal cortex (rIFC) as well as in exploratory ROIs defined by published meta-analyses. STN DBS-induced WM and RI changes (Spatial Delayed Response and Go-No-Go on the next day) were measured in 24 PD participants. On both days, participants withheld PD medications overnight and conditions (OFF vs. ON) were administered in a counterbalanced, double-blind manner. RESULTS: As predicted, STN DBS-induced DLPFC blood flow change correlated with change in WM, but not RI performance. Furthermore, ACC blood flow change correlated with change in RI but not WM performance. For both relationships, increased blood flow related to decreased cognitive performance in response to STN DBS. Of the exploratory regions, only blood flow changes in DLPFC and ACC were correlated with performance. CONCLUSIONS: These results demonstrate that variability in the effects of STN DBS on cognitive performance relates to STN DBS-induced cortical blood flow changes in DLPFC and ACC. This relationship highlights the need to further understand the factors that mediate the variability in neural and cognitive response to STN DBS.
BACKGROUND: Although deep brain stimulation of the subthalamic nucleus (STNDBS) in Parkinson disease (PD) improves motor function, it has variable effects on working memory (WM) and response inhibition (RI) performance. The purpose of this study was to determine the neural correlates of STNDBS-induced variability in cognitive performance. METHODS: We measured bilateral STNDBS-induced blood flow changes (PET and [(15)O]-water on one day) in the supplementary motor area (SMA), dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), and right inferior frontal cortex (rIFC) as well as in exploratory ROIs defined by published meta-analyses. STNDBS-induced WM and RI changes (Spatial Delayed Response and Go-No-Go on the next day) were measured in 24 PDparticipants. On both days, participants withheld PD medications overnight and conditions (OFF vs. ON) were administered in a counterbalanced, double-blind manner. RESULTS: As predicted, STNDBS-induced DLPFC blood flow change correlated with change in WM, but not RI performance. Furthermore, ACC blood flow change correlated with change in RI but not WM performance. For both relationships, increased blood flow related to decreased cognitive performance in response to STNDBS. Of the exploratory regions, only blood flow changes in DLPFC and ACC were correlated with performance. CONCLUSIONS: These results demonstrate that variability in the effects of STNDBS on cognitive performance relates to STNDBS-induced cortical blood flow changes in DLPFC and ACC. This relationship highlights the need to further understand the factors that mediate the variability in neural and cognitive response to STNDBS.
Authors: B Pillon; C Ardouin; P Damier; P Krack; J L Houeto; H Klinger; A M Bonnet; P Pollak; A L Benabid; Y Agid Journal: Neurology Date: 2000-08-08 Impact factor: 9.910
Authors: M Jahanshahi; C M Ardouin; R G Brown; J C Rothwell; J Obeso; A Albanese; M C Rodriguez-Oroz; E Moro; A L Benabid; P Pollak; P Limousin-Dowsey Journal: Brain Date: 2000-06 Impact factor: 13.501
Authors: Tamara Hershey; Meghan C Campbell; Tom O Videen; Heather M Lugar; Patrick M Weaver; Johanna Hartlein; Morvarid Karimi; Samer D Tabbal; Joel S Perlmutter Journal: Brain Date: 2010-09-20 Impact factor: 13.501
Authors: Ahmad Alhourani; Michael M McDowell; Michael J Randazzo; Thomas A Wozny; Efstathios D Kondylis; Witold J Lipski; Sarah Beck; Jordan F Karp; Avniel S Ghuman; R Mark Richardson Journal: J Neurophysiol Date: 2015-08-12 Impact factor: 2.714
Authors: Emily J Knight; Paola Testini; Hoon-Ki Min; William S Gibson; Krzysztof R Gorny; Christopher P Favazza; Joel P Felmlee; Inyong Kim; Kirk M Welker; Daniel A Clayton; Bryan T Klassen; Su-youne Chang; Kendall H Lee Journal: Mayo Clin Proc Date: 2015-06 Impact factor: 7.616
Authors: Sarah A Eisenstein; Jonathan M Koller; Kathleen D Black; Meghan C Campbell; Heather M Lugar; Mwiza Ushe; Samer D Tabbal; Morvarid Karimi; Tamara Hershey; Joel S Perlmutter; Kevin J Black Journal: Ann Neurol Date: 2014-07-02 Impact factor: 10.422