INTRODUCTION: To compare bio, osteocompatibility, rate of resorption and remodeling dynamics of two clinically used bone substitutes. MATERIALS AND METHODS: In a randomized fashion Biobon and Ostim were implanted bilaterally into the proximal metaphyseal tibiae of 18 Göttinger Minipigs in a direct right versus left "intra-individual" comparison. Fluorescent labelling was used. Microradiographic, histological and morphometric evaluation was carried out at 6, 12 and 52 weeks. RESULTS: Both bone substitutes showed good biocompatibility, bioactivity and osteoconductivity. The degradation dynamics of both materials differed. Degradation of Ostim stopped after 6 weeks postoperatively, whereas Biobon was degraded slowly but evenly over the time intervals. Only at 6 weeks a significant (P < 0.05) difference in resorption rate was detected. Both Biobon and Ostim showed incomplete resorption after a year. CONCLUSION: After 1 year no "restitutio ad integrum" could be observed in either group. Similar to ceramics, a thorough osseous incorporation seemed to inhibit further degradation of both bone substitute materials.
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INTRODUCTION: To compare bio, osteocompatibility, rate of resorption and remodeling dynamics of two clinically used bone substitutes. MATERIALS AND METHODS: In a randomized fashion Biobon and Ostim were implanted bilaterally into the proximal metaphyseal tibiae of 18 Göttinger Minipigs in a direct right versus left "intra-individual" comparison. Fluorescent labelling was used. Microradiographic, histological and morphometric evaluation was carried out at 6, 12 and 52 weeks. RESULTS: Both bone substitutes showed good biocompatibility, bioactivity and osteoconductivity. The degradation dynamics of both materials differed. Degradation of Ostim stopped after 6 weeks postoperatively, whereas Biobon was degraded slowly but evenly over the time intervals. Only at 6 weeks a significant (P < 0.05) difference in resorption rate was detected. Both Biobon and Ostim showed incomplete resorption after a year. CONCLUSION: After 1 year no "restitutio ad integrum" could be observed in either group. Similar to ceramics, a thorough osseous incorporation seemed to inhibit further degradation of both bone substitute materials.
Authors: Christina Kim; Matthew R Kendall; Matthew A Miller; Courtney L Long; Preston R Larson; Mary Beth Humphrey; Andrew S Madden; A Cuneyt Tas Journal: Mater Sci Eng C Mater Biol Appl Date: 2013-01-01 Impact factor: 7.328
Authors: Michael L Etheridge; Stephen A Campbell; Arthur G Erdman; Christy L Haynes; Susan M Wolf; Jeffrey McCullough Journal: Nanomedicine Date: 2012-06-06 Impact factor: 5.307
Authors: Christoph Harms; Kai Helms; Tibor Taschner; Ioannis Stratos; Anita Ignatius; Thomas Gerber; Solvig Lenz; Stefan Rammelt; Brigitte Vollmar; Thomas Mittlmeier Journal: Int J Nanomedicine Date: 2012-06-15
Authors: Johannes Keller; Silja Brink; Björn Busse; Arndt F Schilling; Thorsten Schinke; Michael Amling; Tobias Lange Journal: PLoS One Date: 2012-10-10 Impact factor: 3.240