K Albrecht1, K Grob, U Lange, U Müller-Ladner, J Strunk. 1. Department of Rheumatology and Immunology, University of Giessen, Kerckhoff Klinik, Benekestr.2-8, 61231 Bad Nauheim, Germany. k.albrecht@kerckhoff-klinik.de
Abstract
OBJECTIVE: To evaluate the metric qualities of power Doppler ultrasound (PDUS) for different quantification methods and devices in the assessment of arthritis during anti-inflammatory treatment. METHODS: Twenty-four patients with active arthritis and first-time treatment with the TNF-alpha inhibitor adalimumab underwent sequential clinical, laboratory and US examination at baseline, weeks 2, 6 and 12. 2D and 3D PDUS was performed by two independent investigators. The images and movies were scored from 0 to 3 and the amount of colour pixels and voxels was calculated. In addition, the resistance index of a synovial artery was measured. Thirteen patients were examined with a second US machine. RESULTS: Treatment response was already observed at week 2 with a significant reduction of 2D (P < 0.01) and 3D scores (P < 0.001). A moderate correlation to 28-joint disease activity score was found for 3D voxel count (r(s) = 0.35, P < 0.001). Interobserver agreement was kappa or ICC >or= 0.8 for all methods except the resistance index (ICC = 0.60). Intermachine agreement was kappa = 0.57 for 2D PDUS score. CONCLUSIONS: The study demonstrates good to excellent interobserver and moderate intermachine reliability of different PDUS assessment methods in a longitudinal open-label study.
OBJECTIVE: To evaluate the metric qualities of power Doppler ultrasound (PDUS) for different quantification methods and devices in the assessment of arthritis during anti-inflammatory treatment. METHODS: Twenty-four patients with active arthritis and first-time treatment with the TNF-alpha inhibitor adalimumab underwent sequential clinical, laboratory and US examination at baseline, weeks 2, 6 and 12. 2D and 3D PDUS was performed by two independent investigators. The images and movies were scored from 0 to 3 and the amount of colour pixels and voxels was calculated. In addition, the resistance index of a synovial artery was measured. Thirteen patients were examined with a second US machine. RESULTS: Treatment response was already observed at week 2 with a significant reduction of 2D (P < 0.01) and 3D scores (P < 0.001). A moderate correlation to 28-joint disease activity score was found for 3D voxel count (r(s) = 0.35, P < 0.001). Interobserver agreement was kappa or ICC >or= 0.8 for all methods except the resistance index (ICC = 0.60). Intermachine agreement was kappa = 0.57 for 2D PDUS score. CONCLUSIONS: The study demonstrates good to excellent interobserver and moderate intermachine reliability of different PDUS assessment methods in a longitudinal open-label study.
Authors: Andrea S Klauser; Magdalena Franz; Rohit Arora; Gudrun M Feuchtner; Johann Gruber; Michael Schirmer; Werner R Jaschke; Markus F Gabl Journal: Arthritis Res Ther Date: 2010-11-09 Impact factor: 5.156
Authors: Matthew W Seymour; Stephen Kelly; Chan R Beals; Marie-Pierre Malice; James A Bolognese; Bernard J Dardzinski; Amy S Cheng; Corinne E Cummings; Steven S Smugar; Catherine McClinton; Amy Fox; William M Dooley; Constantino Pitzalis; Peter C Taylor Journal: Arthritis Res Ther Date: 2012-09-12 Impact factor: 5.156
Authors: Marina Carotti; Vittoria Galeazzi; Francesca Catucci; Marcello Zappia; Francesco Arrigoni; Antonio Barile; Andrea Giovagnoni Journal: Acta Biomed Date: 2018-01-19