Literature DB >> 18676952

Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids.

Sherry A Castle1, Elizabeth A Owuor, Stephanie H Thompson, Michelle R Garnsey, J Stacey Klutts, Tamara L Doering, Steven B Levery.   

Abstract

The Manalpha1,3(Xylbeta1,2)Manalpha structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylbeta1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.

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Year:  2008        PMID： 18676952      PMCID： PMC2547070          DOI： 10.1128/EC.00458-07

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  19 in total

Review 1.  Glycosphingolipid structural analysis and glycosphingolipidomics.

Authors:  Steven B Levery
Journal:  Methods Enzymol       Date:  2005       Impact factor: 1.600

2.  Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene.

Authors:  M M Nagiec; E E Nagiec; J A Baltisberger; G B Wells; R L Lester; R C Dickson
Journal:  J Biol Chem       Date:  1997-04-11       Impact factor: 5.157

3.  Molecular analysis of a novel family of complex glycoinositolphosphoryl ceramides from Cryptococcus neoformans: structural differences between encapsulated and acapsular yeast forms.

Authors:  Norton Heise; Ana L S Gutierrez; Katherine A Mattos; Christopher Jones; Robin Wait; José O Previato; Lucia Mendonça-Previato
Journal:  Glycobiology       Date:  2002-07       Impact factor: 4.313

4.  UDP-glucose dehydrogenase plays multiple roles in the biology of the pathogenic fungus Cryptococcus neoformans.

Authors:  Cara L Griffith; J Stacey Klutts; Lijuan Zhang; Steven B Levery; Tamara L Doering
Journal:  J Biol Chem       Date:  2004-09-21       Impact factor: 5.157

5.  Structure elucidation of sphingolipids from the mycopathogen Paracoccidioides brasiliensis: an immunodominant beta-galactofuranose residue is carried by a novel glycosylinositol phosphorylceramide antigen.

Authors:  S B Levery; M S Toledo; A H Straus; H K Takahashi
Journal:  Biochemistry       Date:  1998-06-16       Impact factor: 3.162

Review 6.  Yeast sphingolipids.

Authors:  R C Dickson; R L Lester
Journal:  Biochim Biophys Acta       Date:  1999-01-06

7.  Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans.

Authors:  Ana L S Gutierrez; Layla Farage; Manuel N Melo; Ronaldo S Mohana-Borges; Yann Guerardel; Bernadete Coddeville; Jean-Michel Wieruszeski; Lucia Mendonça-Previato; Jose O Previato
Journal:  Glycobiology       Date:  2007-03-16       Impact factor: 4.313

8.  Glycosphingolipids of the model fungus Aspergillus nidulans: characterization of GIPCs with oligo-alpha-mannose-type glycans.

Authors:  Beau Bennion; Chaeho Park; Matthew Fuller; Rebecca Lindsey; Michelle Momany; Richard Jennemann; Steven B Levery
Journal:  J Lipid Res       Date:  2003-08-16       Impact factor: 5.922

Review 9.  Sphingolipids with inositolphosphate-containing head groups.

Authors:  R L Lester; R C Dickson
Journal:  Adv Lipid Res       Date:  1993

Review 10.  Sphingolipid functions in Saccharomyces cerevisiae.

Authors:  Robert C Dickson; Robert L Lester
Journal:  Biochim Biophys Acta       Date:  2002-06-13
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  16 in total

1.  Cryptococcus neoformans Evades Pulmonary Immunity by Modulating Xylose Precursor Transport.

Authors:  Lucy X Li; Camaron R Hole; Javier Rangel-Moreno; Shabaana A Khader; Tamara L Doering
Journal:  Infect Immun       Date:  2020-07-21       Impact factor: 3.441

2.  A xylosylphosphotransferase of Cryptococcus neoformans acts in protein O-glycan synthesis.

Authors:  Morgann C Reilly; Kazuhiro Aoki; Zhuo A Wang; Michael L Skowyra; Matthew Williams; Michael Tiemeyer; Tamara L Doering
Journal:  J Biol Chem       Date:  2011-05-23       Impact factor: 5.157

3.  Unraveling unique structure and biosynthesis pathway of N-linked glycans in human fungal pathogen Cryptococcus neoformans by glycomics analysis.

Authors:  Jeong-Nam Park; Dong-Jik Lee; Ohsuk Kwon; Doo-Byoung Oh; Yong-Sun Bahn; Hyun Ah Kang
Journal:  J Biol Chem       Date:  2012-04-12       Impact factor: 5.157

Review 4.  Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.

Authors:  Kyung J Kwon-Chung; James A Fraser; Tamara L Doering; Zhou Wang; Guilhem Janbon; Alexander Idnurm; Yong-Sun Bahn
Journal:  Cold Spring Harb Perspect Med       Date:  2014-07-01       Impact factor: 6.915

5.  Cryptococcus neoformans UGT1 encodes a UDP-Galactose/UDP-GalNAc transporter.

Authors:  Lucy X Li; Angel Ashikov; Hong Liu; Cara L Griffith; Hans Bakker; Tamara L Doering
Journal:  Glycobiology       Date:  2016-08-03       Impact factor: 4.313

Review 6.  How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans.

Authors:  Tamara Lea Doering
Journal:  Annu Rev Microbiol       Date:  2009       Impact factor: 15.500

7.  A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans.

Authors:  Morgann C Reilly; Steven B Levery; Sherry A Castle; J Stacey Klutts; Tamara L Doering
Journal:  J Biol Chem       Date:  2009-10-28       Impact factor: 5.157

Review 8.  The capsule of the fungal pathogen Cryptococcus neoformans.

Authors:  Oscar Zaragoza; Marcio L Rodrigues; Magdia De Jesus; Susana Frases; Ekaterina Dadachova; Arturo Casadevall
Journal:  Adv Appl Microbiol       Date:  2009       Impact factor: 5.086

9.  Identification of the galactosyltransferase of Cryptococcus neoformans involved in the biosynthesis of basidiomycete-type glycosylinositolphosphoceramide.

Authors:  Therese Wohlschlager; Reto Buser; Michael L Skowyra; Brian C Haynes; Bernard Henrissat; Tamara L Doering; Markus Künzler; Markus Aebi
Journal:  Glycobiology       Date:  2013-08-06       Impact factor: 4.313

Review 10.  Virulence-Associated Enzymes of Cryptococcus neoformans.

Authors:  Fausto Almeida; Julie M Wolf; Arturo Casadevall
Journal:  Eukaryot Cell       Date:  2015-10-09
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