BACKGROUND: Case reports of primary pulmonary artery sarcomas are very rare. METHODS: We described herein eight new cases diagnosed between December 2000 and December 2004. RESULTS: There were four men and four women, with median age of 52 years. Presenting symptoms mimicked pulmonary emboli in all cases. There were six "intimal sarcomas" and two leiomyosarcomas. In six cases, we observed initial metastasis in lung (six cases), in bone (two cases), and in brain (two cases), and adrenal gland (one case). The palliative treatments included surgical desobstruction (six cases), conformational radiotherapy (four cases), and chemotherapy (seven cases). Doxorubicin-based regimen failed in seven cases. All patients died (median survival: 8 months, extremes 5-20 months). CONCLUSION: Those eight cases illustrate the high incidence of initial metastasis and the very poor outcome of primary pulmonary artery sarcomas despite classic doxorubicin-based chemotherapy.
BACKGROUND: Case reports of primary pulmonary artery sarcomas are very rare. METHODS: We described herein eight new cases diagnosed between December 2000 and December 2004. RESULTS: There were four men and four women, with median age of 52 years. Presenting symptoms mimicked pulmonary emboli in all cases. There were six "intimal sarcomas" and two leiomyosarcomas. In six cases, we observed initial metastasis in lung (six cases), in bone (two cases), and in brain (two cases), and adrenal gland (one case). The palliative treatments included surgical desobstruction (six cases), conformational radiotherapy (four cases), and chemotherapy (seven cases). Doxorubicin-based regimen failed in seven cases. All patients died (median survival: 8 months, extremes 5-20 months). CONCLUSION: Those eight cases illustrate the high incidence of initial metastasis and the very poor outcome of primary pulmonary artery sarcomas despite classic doxorubicin-based chemotherapy.
Authors: Debabrata Bandyopadhyay; Tanmay S Panchabhai; Navkaranbir S Bajaj; Pradnya D Patil; Matthew C Bunte Journal: J Thorac Dis Date: 2016-09 Impact factor: 2.895
Authors: Anna Maria Frezza; Tarek Assi; Salvatore Lo Vullo; Eytan Ben-Ami; Armelle Dufresne; Kan Yonemori; Emi Noguchi; Brittany Siontis; Richard Ferraro; Pawel Teterycz; Florence Duffaud; Vinod Ravi; Bruno Vincenzi; Hans Gelderblom; Maria A Pantaleo; Giacomo G Baldi; Ingrid Desar; Alexander Fedenko; Robert G Maki; Robin L Jones; Robert S Benjamin; Jean Yves Blay; Akira Kawai; Mrinal Gounder; Alessandro Gronchi; Axel Le Cesne; Olivier Mir; Anna M Czarnecka; Scott Schuetze; Andrew J Wagner; Julien Adam; Marta Barisella; Marta Sbaraglia; Jason L Hornick; Alexandra Meurgey; Luigi Mariani; Paolo G Casali; Katherine Thornton; Silvia Stacchiotti Journal: Cancer Date: 2019-09-19 Impact factor: 6.921
Authors: Karim Abdur Rehman; Jorge Betancor; Bo Xu; Carmela D Tan; E Rene Rodriguez; Craig R Asher; Allan L Klein Journal: CASE (Phila) Date: 2017-06-26