BACKGROUND: Depressive symptoms are common in middle aged and older patients with schizophrenia. The authors hypothesized that worse functioning in these patients would be associated with worse psychopathology. METHODS: Outpatients with schizophrenia were > or =40 years old with subsyndromal depression and Hamilton Depression Rating Scale Scores of > or =8. Exclusions were dementia, two months of either mania or major depression or 1 month active substance abuse/dependence. The authors administered performance based functional assessments, the Positive and Negative Syndrome Scale of Schizophrenia [PANSS], and Calgary Depression Rating Scale. RESULTS: PANSS (-) scores were negatively correlated with the UCSD Performance Skills Based Assessment, Social Skills Performance Assessment and Medication Management Ability Assessment total error (MMAA) scores. Digit symbol scores served as a moderator of the relationship between MMAA and PANSS (-) scores. CONCLUSIONS: Negative symptoms were associated with functioning. The relationship between negative symptoms and medication errors seem to weaken in subjects with quicker processing speed.
BACKGROUND:Depressive symptoms are common in middle aged and older patients with schizophrenia. The authors hypothesized that worse functioning in these patients would be associated with worse psychopathology. METHODS: Outpatients with schizophrenia were > or =40 years old with subsyndromal depression and Hamilton Depression Rating Scale Scores of > or =8. Exclusions were dementia, two months of either mania or major depression or 1 month active substance abuse/dependence. The authors administered performance based functional assessments, the Positive and Negative Syndrome Scale of Schizophrenia [PANSS], and Calgary Depression Rating Scale. RESULTS: PANSS (-) scores were negatively correlated with the UCSD Performance Skills Based Assessment, Social Skills Performance Assessment and Medication Management Ability Assessment total error (MMAA) scores. Digit symbol scores served as a moderator of the relationship between MMAA and PANSS (-) scores. CONCLUSIONS: Negative symptoms were associated with functioning. The relationship between negative symptoms and medication errors seem to weaken in subjects with quicker processing speed.
Authors: Sidney Zisook; Maren Nyer; John Kasckow; Shah Golshan; David Lehman; Lori Montross Journal: Schizophr Res Date: 2006-06-05 Impact factor: 4.939
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Authors: S Zisook; L A McAdams; J Kuck; M J Harris; A Bailey; T L Patterson; L L Judd; D V Jeste Journal: Am J Psychiatry Date: 1999-11 Impact factor: 18.112
Authors: T L Patterson; J C Klapow; J H Eastham; R K Heaton; J D Evans; W L Koch; D V Jeste Journal: Psychiatry Res Date: 1998-07-27 Impact factor: 3.222
Authors: Jessica M Brooks; John Blake; Jennifer Sánchez; Elias Mpofu; Jia-Rung Wu; Xiangli Chen; Jonathan Nauser; Brandi P Cotton; Stephen J Bartels Journal: Community Ment Health J Date: 2019-05-16
Authors: John Kasckow; Nicole Lanouette; Thomas Patterson; Ian Fellows; Shahrokh Golshan; Ellen Solorzano; Sidney Zisook Journal: Int J Geriatr Psychiatry Date: 2010-02 Impact factor: 3.485
Authors: Ipsit V Vahia; Nicole M Lanouette; Shahrokh Golshan; Ian Fellows; Somaia Mohamed; John W Kasckow; Sidney Zisook Journal: Indian J Psychiatry Date: 2013-04 Impact factor: 1.759