Literature DB >> 17551352

Schizoaffective disorder merges schizophrenia and bipolar disorders as one disease--there is no schizoaffective disorder.

Charles Ray Lake1, Nathaniel Hurwitz.   

Abstract

PURPOSE OF REVIEW: Schizoaffective disorder was named as a compromise diagnosis in 1933, and remains popular as judged by its place in the International Classification of Diseases and the Diagnostic and Statistical Manual of Mental Disorders, its frequent use in clinical practice, and its extensive discussion in the literature. Some, however, have questioned the validity of schizoaffective disorder as separate from psychotic mood disorder. We examined the literature to assess the rationale for the continuation of schizoaffective disorder as a legitimate diagnostic category. RECENT
FINDINGS: The diagnosis of schizoaffective disorder depends on the disease specificity of the diagnostic criteria for schizophrenia; however, the psychotic symptoms for schizophrenia, traditionally held as specific, can be accounted for by psychotic bipolar. Further, the interrater reliability for diagnosing schizoaffective disorder is very low. A recent and expanding body of comparative evidence from a wide range of clinical and basic science studies, especially genetic, reveals multiple similarities between schizoaffective disorder, schizophrenia and psychotic bipolar.
SUMMARY: Schizoaffective disorder unifies schizophrenia and bipolar, blurring the zones of rarity between them and suggesting that schizoaffective disorder is not a separate, 'bona-fide' disease. Patients diagnosed with schizoaffective disorder likely suffer from a psychotic mood disorder. The diagnosis of schizoaffective disorder, which can result in substandard treatment, should be eliminated from the diagnostic nomenclature.

Entities:  

Mesh:

Year:  2007        PMID: 17551352     DOI: 10.1097/YCO.0b013e3281a305ab

Source DB:  PubMed          Journal:  Curr Opin Psychiatry        ISSN: 0951-7367            Impact factor:   4.741


  28 in total

1.  [Neuroimaging markers: their role for differential diagnosis and therapeutic decisions in personalized psychiatry].

Authors:  O Gruber
Journal:  Nervenarzt       Date:  2011-11       Impact factor: 1.214

2.  At the edge of the bipolar spectrum: primacy of affective over psychotic symptoms or vice versa?

Authors:  Heinz Grunze
Journal:  World Psychiatry       Date:  2011-10       Impact factor: 49.548

3.  Current psychopathological issues in psychosis: towards a phenome-wide scanning approach.

Authors:  Manuel J Cuesta; Victor Peralta
Journal:  Schizophr Bull       Date:  2008-05-14       Impact factor: 9.306

4.  Kynurenine is correlated with IL-1β in plasma of schizophrenia patients.

Authors:  Helena P G Joaquim; Alana C Costa; Wagner F Gattaz; Leda Leme Talib
Journal:  J Neural Transm (Vienna)       Date:  2018-01-06       Impact factor: 3.575

5.  Tackling the Kraepelinian Dichotomy: a Neuroimaging Review.

Authors:  Alan R Prossin; Melvin G McInnis; Amit Anand; Mary M Heitzeg; Jon-Kar Zubieta
Journal:  Psychiatr Ann       Date:  2010-03

6.  Functioning in middle aged and older patients with schizophrenia and depressive symptoms: relationship to psychopathology.

Authors:  John Kasckow; Thomas Patterson; Ian Fellows; Shahrokh Golshan; Ellen Solorzano; Somaia Mohamed; Sidney Zisook
Journal:  Am J Geriatr Psychiatry       Date:  2008-08       Impact factor: 4.105

7.  Neurophysiological Distinction between Schizophrenia and Schizoaffective Disorder.

Authors:  Daniel H Mathalon; Ralph E Hoffman; Todd D Watson; Ryan M Miller; Brian J Roach; Judith M Ford
Journal:  Front Hum Neurosci       Date:  2010-01-29       Impact factor: 3.169

8.  Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.

Authors:  M L Hamshere; E K Green; I R Jones; L Jones; V Moskvina; G Kirov; D Grozeva; I Nikolov; D Vukcevic; S Caesar; K Gordon-Smith; C Fraser; E Russell; G Breen; D St Clair; D A Collier; A H Young; I N Ferrier; A Farmer; P McGuffin; P A Holmans; M J Owen; M C O'Donovan; N Craddock
Journal:  Br J Psychiatry       Date:  2009-07       Impact factor: 9.319

9.  Early-onset psychoses: comparison of clinical features and adult outcome in 3 diagnostic groups.

Authors:  Maria Giuseppina Ledda; Anna Lisa Fratta; Manuela Pintor; Alessandro Zuddas; Carlo Cianchetti
Journal:  Child Psychiatry Hum Dev       Date:  2009-03-12

10.  Bridging the gap between schizophrenia and psychotic mood disorders: Relating neurocognitive deficits to psychopathology.

Authors:  Matthew J Smith; Deanna M Barch; John G Csernansky
Journal:  Schizophr Res       Date:  2008-09-10       Impact factor: 4.939

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