| Literature DB >> 18668436 |
M Pastor-Anglada1, P Cano-Soldado, E Errasti-Murugarren, F J Casado.
Abstract
The human concentrative nucleoside transporter (hCNT) protein family has three members, hCNT1, 2, and 3, encoded by SLC28A1, A2, and A3 genes, respectively. hCNT1 and hCNT2 translocate pyrimidine- and purine-nucleosides, respectively, by a sodium-dependent mechanism, whereas hCNT3 shows broad substrate selectivity and the unique ability of translocating nucleosides both in a sodium- and a proton-coupled manner. hCNT proteins are also responsible for the uptake of most nucleoside-derived antiviral and anticancer drugs. Thus, hCNTs are key pharmacological targets. This review focuses on several crucial aspects of hCNT biology and pharmacology: protein structure-function, structural determinants for transportability, pharmacogenetics of hCNT-encoding genes, role of hCNT proteins in nucleoside-based therapeutics, and finally hCNT physiology.Entities:
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Year: 2008 PMID： 18668436 DOI： 10.1080/00498250802069096
Source DB: PubMed Journal: Xenobiotica ISSN： 0049-8254 Impact factor: 1.908