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Literature DB >> 18667147

Linking calcium to Abeta and Alzheimer's disease.

Abstract

Recent developments point to a critical role for calcium dysregulation in the pathogenesis of Alzheimer's disease. A novel calcium-conducting channel called CALHM1 is genetically linked to the disorder and modulates Abeta production. Calcium homeostasis has also been shown to be perturbed in dendritic spines adjacent to amyloid plaques. Finally, new studies have elucidated the role by which presenilins modulate calcium signaling, including effects on SERCA2b and gating of the IP(3) receptor, and lead to Abeta production.

Entities: Chemical Disease Gene

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Year: 2008 PMID： 18667147 DOI： 10.1016/j.neuron.2008.07.013

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

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Cited

119 in total

1. Single-cell screening of cytosolic [Ca(2+)] reveals cell-selective action by the Alzheimer's Aβ peptide ion channel.

Authors: Hopi Lin; Nelson J Arispe
Journal: Cell Stress Chaperones Date: 2014-11-01 Impact factor: 3.667

Review 2. Calcium and mitochondrial reactive oxygen species generation: how to read the facts.

Authors: Vera Adam-Vizi; Anatoly A Starkov
Journal: J Alzheimers Dis Date: 2010 Impact factor: 4.472

3. Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's.

Authors: Lisa Mosconi; Juha O Rinne; Wai H Tsui; Valentina Berti; Yi Li; Huiyu Wang; John Murray; Noora Scheinin; Kjell Någren; Schantel Williams; Lidia Glodzik; Susan De Santi; Shankar Vallabhajosula; Mony J de Leon
Journal: Proc Natl Acad Sci U S A Date: 2010-03-15 Impact factor: 11.205

4. Membrane cholesterol modulates {beta}-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of N-methyl-D-aspartic acid receptors.

Authors: Alexandra M Nicholson; D Nicole Riherd Methner; Adriana Ferreira
Journal: J Biol Chem Date: 2010-11-03 Impact factor: 5.157

10. Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity.

Authors: Li Yang; Zilai Wang; Baiping Wang; Nicholas J Justice; Hui Zheng
Journal: J Neurosci Date: 2009-12-16 Impact factor: 6.167

Linking calcium to Abeta and Alzheimer's disease.

1. Single-cell screening of cytosolic [Ca(2+)] reveals cell-selective action by the Alzheimer's Aβ peptide ion channel.

Review 2. Calcium and mitochondrial reactive oxygen species generation: how to read the facts.

3. Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's.

4. Membrane cholesterol modulates {beta}-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of N-methyl-D-aspartic acid receptors.

5. Rosuvastatin and thapsigargin modulate γ-secretase gene expression and APP processing in a human neuroglioma model.

6. Photochemically initiated intracellular astrocytic calcium waves in living mice using two-photon uncaging of IP(3).

7. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats.

Review 8. The Essential Role of Soluble Aβ Oligomers in Alzheimer's Disease.

9. Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

10. Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity.