AIM: To examine the possible role of the Epstein-Barr Virus (EBV) in the development of gastric adenocarcinoma (GC). It is unclear whether EBV is involved in GC development or is a consequence of gastric inflammation secondary to immunosuppressive treatments. METHODS: A systematic review was carried out of all published observational studies on the temporal association between EBV and GC, with a view to determine a causal relationship. RESULTS: The present study showed that the worldwide crude prevalence of EBV in gastric adenocarcinoma was 8.29%. The prevalence varied from 7.08% for intestinal type and 9.82% for diffuse type of GC. It was observed that Western and Central Asian countries had a significantly higher frequency of EBV positive cases compared to South-Eastern countries. America had the highest EBV-GC prevalence whereas Europe had the lowest. CONCLUSION: The present review has demonstrated a high prevalence of EBV in gastric adenocarcinoma. However, studies designed to assess a temporal relationship and histological association using sensitive techniques should be carried out to establish the role of EBV in GC carcinogenesis.
AIM: To examine the possible role of the Epstein-Barr Virus (EBV) in the development of gastric adenocarcinoma (GC). It is unclear whether EBV is involved in GC development or is a consequence of gastric inflammation secondary to immunosuppressive treatments. METHODS: A systematic review was carried out of all published observational studies on the temporal association between EBV and GC, with a view to determine a causal relationship. RESULTS: The present study showed that the worldwide crude prevalence of EBV in gastric adenocarcinoma was 8.29%. The prevalence varied from 7.08% for intestinal type and 9.82% for diffuse type of GC. It was observed that Western and Central Asian countries had a significantly higher frequency of EBV positive cases compared to South-Eastern countries. America had the highest EBV-GC prevalence whereas Europe had the lowest. CONCLUSION: The present review has demonstrated a high prevalence of EBV in gastric adenocarcinoma. However, studies designed to assess a temporal relationship and histological association using sensitive techniques should be carried out to establish the role of EBV in GC carcinogenesis.
Authors: A Corvalan; C Koriyama; S Akiba; Y Eizuru; C Backhouse; M Palma; J Argandoña; M Tokunaga Journal: Int J Cancer Date: 2001-11 Impact factor: 7.396
Authors: E Yoshiwara; C Koriyama; S Akiba; T Itoh; Y Minakami; J L Chirinos; J Watanabe; J Takano; J Miyagui; H Hidalgo; P Chacon; V Linares; Y Eizuru Journal: J Exp Clin Cancer Res Date: 2005-03
Authors: S A Galetsky; V V Tsvetnov; C E Land; T A Afanasieva; N N Petrovichev; V E Gurtsevitch; M Tokunaga Journal: Int J Cancer Date: 1997-12-10 Impact factor: 7.396
Authors: Jayasree Kattoor; Chihaya Koriyama; Suminori Akiba; Tetsuhiko Itoh; Shan Ding; Yoshito Eizuru; Elizabeth K Abraham; B Chandralekha; N S Amma; M Krishnan Nair Journal: J Med Virol Date: 2002-11 Impact factor: 2.327
Authors: U Yalçıntaş Arslan; B Öksüzoğlu; F O Onder; C Irkkan; U Üyetürk; N Gökbayrak; N Alkış Journal: Med Oncol Date: 2010-02-09 Impact factor: 3.064