BACKGROUND: Recent studies indicate that arterial cardiovascular diseases and venous thromboembolism (VTE) share common risk factors. A family history of myocardial infarction (MI) is a strong and independent risk factor for future MI. OBJECTIVES: The purpose of the present study was to determine the impact of cardiovascular risk factors, including family history of MI, on the incidence of VTE in a prospective, population-based study. PATIENTS AND METHODS: Traditional cardiovascular risk factors and family history of MI were registered in 21,330 subjects, aged 25-96 years, enrolled in the Tromsø study in 1994-95. First-lifetime VTE events during follow-up were registered up to 1 September 2007. RESULTS: There were 327 VTE events (1.40 per 1000 person-years), 138 (42%) unprovoked, during a mean of 10.9 years of follow-up. In age- and gender-adjusted analysis, age [hazard ratio (HR) per decade, 1.97; 95% confidence interval (CI), 1.82-2.12], gender (men vs. women; HR, 1.25; 95% CI, 1.01-1.55), body mass index (BMI; HR per 3 kg m(-2), 1.21; 95% CI, 1.13-1.31), and family history of MI (HR, 1.31; 95% CI, 1.04-1.65) were significantly associated with VTE. Family history of MI remained a significant risk factor for total VTE (HR, 1.27; 95% CI, 1.01-1.60) and unprovoked VTE (HR, 1.46; 95% CI, 1.03-2.07) in multivariable analysis. Blood pressure, total cholesterol, HDL-cholesterol, triglycerides, and smoking were not independently associated with total VTE. CONCLUSIONS: Family history of MI is a risk factor for both MI and VTE, and provides further evidence of a link between venous and arterial thrombosis.
BACKGROUND: Recent studies indicate that arterial cardiovascular diseases and venous thromboembolism (VTE) share common risk factors. A family history of myocardial infarction (MI) is a strong and independent risk factor for future MI. OBJECTIVES: The purpose of the present study was to determine the impact of cardiovascular risk factors, including family history of MI, on the incidence of VTE in a prospective, population-based study. PATIENTS AND METHODS: Traditional cardiovascular risk factors and family history of MI were registered in 21,330 subjects, aged 25-96 years, enrolled in the Tromsø study in 1994-95. First-lifetime VTE events during follow-up were registered up to 1 September 2007. RESULTS: There were 327 VTE events (1.40 per 1000 person-years), 138 (42%) unprovoked, during a mean of 10.9 years of follow-up. In age- and gender-adjusted analysis, age [hazard ratio (HR) per decade, 1.97; 95% confidence interval (CI), 1.82-2.12], gender (men vs. women; HR, 1.25; 95% CI, 1.01-1.55), body mass index (BMI; HR per 3 kg m(-2), 1.21; 95% CI, 1.13-1.31), and family history of MI (HR, 1.31; 95% CI, 1.04-1.65) were significantly associated with VTE. Family history of MI remained a significant risk factor for total VTE (HR, 1.27; 95% CI, 1.01-1.60) and unprovoked VTE (HR, 1.46; 95% CI, 1.03-2.07) in multivariable analysis. Blood pressure, total cholesterol, HDL-cholesterol, triglycerides, and smoking were not independently associated with total VTE. CONCLUSIONS: Family history of MI is a risk factor for both MI and VTE, and provides further evidence of a link between venous and arterial thrombosis.
Authors: Solveig Gretarsdottir; Annette F Baas; Gudmar Thorleifsson; Hilma Holm; Martin den Heijer; Jean-Paul P M de Vries; Steef E Kranendonk; Clark J A M Zeebregts; Steven M van Sterkenburg; Robert H Geelkerken; Andre M van Rij; Michael J A Williams; Albert P M Boll; Jelena P Kostic; Adalbjorg Jonasdottir; Aslaug Jonasdottir; G Bragi Walters; Gisli Masson; Patrick Sulem; Jona Saemundsdottir; Magali Mouy; Kristinn P Magnusson; Gerard Tromp; James R Elmore; Natzi Sakalihasan; Raymond Limet; Jean-Olivier Defraigne; Robert E Ferrell; Antti Ronkainen; Ynte M Ruigrok; Cisca Wijmenga; Diederick E Grobbee; Svati H Shah; Christopher B Granger; Arshed A Quyyumi; Viola Vaccarino; Riyaz S Patel; A Maziar Zafari; Allan I Levey; Harland Austin; Domenico Girelli; Pier Franco Pignatti; Oliviero Olivieri; Nicola Martinelli; Giovanni Malerba; Elisabetta Trabetti; Lewis C Becker; Diane M Becker; Muredach P Reilly; Daniel J Rader; Thomas Mueller; Benjamin Dieplinger; Meinhard Haltmayer; Sigitas Urbonavicius; Bengt Lindblad; Anders Gottsäter; Eleonora Gaetani; Roberto Pola; Philip Wells; Marc Rodger; Melissa Forgie; Nicole Langlois; Javier Corral; Vicente Vicente; Jordi Fontcuberta; Francisco España; Niels Grarup; Torben Jørgensen; Daniel R Witte; Torben Hansen; Oluf Pedersen; Katja K Aben; Jacqueline de Graaf; Suzanne Holewijn; Lasse Folkersen; Anders Franco-Cereceda; Per Eriksson; David A Collier; Hreinn Stefansson; Valgerdur Steinthorsdottir; Thorunn Rafnar; Einar M Valdimarsson; Hulda B Magnadottir; Sigurlaug Sveinbjornsdottir; Isleifur Olafsson; Magnus Karl Magnusson; Robert Palmason; Vilhelmina Haraldsdottir; Karl Andersen; Pall T Onundarson; Gudmundur Thorgeirsson; Lambertus A Kiemeney; Janet T Powell; David J Carey; Helena Kuivaniemi; Jes S Lindholt; Gregory T Jones; Augustine Kong; Jan D Blankensteijn; Stefan E Matthiasson; Unnur Thorsteinsdottir; Kari Stefansson Journal: Nat Genet Date: 2010-07-11 Impact factor: 38.330
Authors: S K Braekkan; S D Grosse; E M Okoroh; J Tsai; S C Cannegieter; I A Naess; S Krokstad; J-B Hansen; F E Skjeldestad Journal: J Thromb Haemost Date: 2016-08-17 Impact factor: 5.824
Authors: Marja K Puurunen; Philimon N Gona; Martin G Larson; Joanne M Murabito; Jared W Magnani; Christopher J O'Donnell Journal: Thromb Res Date: 2016-06-29 Impact factor: 3.944