Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A novel function of adenomatous polyposis coli (APC) in regulating DNA repair.

Literature DB >> 18662849

A novel function of adenomatous polyposis coli (APC) in regulating DNA repair.

Abstract

Prevailing literature suggests diversified cellular functions for the adenomatous polyposis coli (APC) gene. Among them a recently discovered unique role of APC is in DNA repair. The APC gene can modulate the base excision repair (BER) pathway through an interaction with DNA polymerase beta (Pol-beta) and flap endonuclease 1 (Fen-1). Taken together with the transcriptional activation of APC gene by alkylating agents and modulation of BER activity, APC may play an important role in carcinogenesis and chemotherapy by determining whether cells with DNA damage survive or undergo apoptosis. In this review, we summarize the evidence supporting this novel concept and suggest that these results will have implications for the development of more effective strategies for chemoprevention, prognosis and chemotherapy of certain types of tumors.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2008 PMID： 18662849 PMCID： PMC2585005 DOI： 10.1016/j.canlet.2008.06.024

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

80 in total

1. Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

Authors: B Demple; T Herman; D S Chen
Journal: Proc Natl Acad Sci U S A Date: 1991-12-15 Impact factor: 11.205

2. Wild-type but not mutant APC associates with the microtubule cytoskeleton.

Authors: K J Smith; D B Levy; P Maupin; T D Pollard; B Vogelstein; K W Kinzler
Journal: Cancer Res Date: 1994-07-15 Impact factor: 12.701

3. The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

Authors: S Munemitsu; B Souza; O Müller; I Albert; B Rubinfeld; P Polakis
Journal: Cancer Res Date: 1994-07-15 Impact factor: 12.701

4. Microsatellite instability in cancer of the proximal colon.

Authors: S N Thibodeau; G Bren; D Schaid
Journal: Science Date: 1993-05-07 Impact factor: 47.728

5. APC mutations occur early during colorectal tumorigenesis.

Authors: S M Powell; N Zilz; Y Beazer-Barclay; T M Bryan; S R Hamilton; S N Thibodeau; B Vogelstein; K W Kinzler
Journal: Nature Date: 1992-09-17 Impact factor: 49.962

6. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.

Authors: Y Miyoshi; H Nagase; H Ando; A Horii; S Ichii; S Nakatsuru; T Aoki; Y Miki; T Mori; Y Nakamura
Journal: Hum Mol Genet Date: 1992-07 Impact factor: 6.150

7. Further evidence that one of the earliest alterations in colorectal carcinogenesis involves APC.

Authors: J Tsao; D Shibata
Journal: Am J Pathol Date: 1994-09 Impact factor: 4.307

8. DNA polymerase beta mutations in human colorectal cancer.

Authors: L Wang; U Patel; L Ghosh; S Banerjee
Journal: Cancer Res Date: 1992-09-01 Impact factor: 12.701

9. Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients.

Authors: H Nagase; Y Miyoshi; A Horii; T Aoki; M Ogawa; J Utsunomiya; S Baba; T Sasazuki; Y Nakamura
Journal: Cancer Res Date: 1992-07-15 Impact factor: 12.701

10. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair.

Authors: Y Matsumoto; K Kim
Journal: Science Date: 1995-08-04 Impact factor: 47.728

32 in total

Review 1. Targeting DNA polymerase ß for therapeutic intervention.

Authors: Eva M Goellner; David Svilar; Karen H Almeida; Robert W Sobol
Journal: Curr Mol Pharmacol Date: 2012-01 Impact factor: 3.339

Review 2. Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.

Authors: Satya Narayan; Ritika Sharma
Journal: Life Sci Date: 2015-09-01 Impact factor: 5.037

3. Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity.

Authors: Aruna S Jaiswal; Satya Narayan
Journal: Biochemistry Date: 2011-02-04 Impact factor: 3.162

Review 4. Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.

Authors: Lu Zhang; Jerry W Shay
Journal: J Natl Cancer Inst Date: 2017-08-01 Impact factor: 13.506

Review 5. Interaction between APC and Fen1 during breast carcinogenesis.

Authors: Satya Narayan; Aruna S Jaiswal; Brian K Law; Mohammad A Kamal; Arun K Sharma; Robert A Hromas
Journal: DNA Repair (Amst) Date: 2016-04-07

Review 6. Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.

Authors: Ajay Srinivasan; Barry Gold
Journal: Future Med Chem Date: 2012-06 Impact factor: 3.808

7. A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.

Authors: Aruna S Jaiswal; Sanjeev Banerjee; Harekrushna Panda; Charles D Bulkin; Tadahide Izumi; Fazlul H Sarkar; David A Ostrov; Satya Narayan
Journal: Mol Cancer Res Date: 2009-12-08 Impact factor: 5.852