Literature DB >> 18662770

A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice.

Kenneth R Johnson1, Chantal Longo-Guess, Leona H Gagnon, Heping Yu, Qing Yin Zheng.   

Abstract

The DBA/2J inbred strain of mice is used extensively in hearing research, yet little is known about the genetic basis for its early onset, progressive hearing loss. To map underlying genetic factors we analyzed recombinant inbred strains and linkage backcrosses. Analysis of 213 mice from 31 BXD recombinant inbred strains detected linkage of auditory brain-stem response thresholds with a locus on distal chromosome 11, which we designate ahl8. Analysis of 225 N2 mice from a backcross of (C57BL/6JxDBA/2J) F1 hybrids to DBA/2J mice confirmed this linkage (LOD>50) and refined the ahl8 candidate gene interval. Analysis of 214 mice from a backcross of (B6.CAST-Cdh23 Ahl+ xDBA/2J) F1 hybrids to DBA/2J mice demonstrated a genetic interaction of Cdh23 with ahl8. We conclude that ahl8 is a major contributor to the hearing loss of DBA/2J mice and that its effects are dependent on the predisposing Cdh23 ahl genotype of this strain.

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Year:  2008        PMID： 18662770      PMCID： PMC2836023          DOI： 10.1016/j.ygeno.2008.06.007

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  45 in total

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3.  Ahl2, a second locus affecting age-related hearing loss in mice.

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4.  Genealogies of mouse inbred strains.

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5.  Genomewide linkage analysis to presbycusis in the Framingham Heart Study.

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6.  A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice.

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9.  Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss.

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  31 in total

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6.  Otoprotective effects of mouse nerve growth factor in DBA/2J mice with early-onset progressive hearing loss.

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7.  Synaptic transmission at the endbulb of Held deteriorates during age-related hearing loss.

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8.  Auditory nerve synapses persist in ventral cochlear nucleus long after loss of acoustic input in mice with early-onset progressive hearing loss.

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Review 9.  Inheritance patterns of progressive hearing loss in laboratory strains of mice.

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10.  Genome-wide association study for age-related hearing loss (AHL) in the mouse: a meta-analysis.

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