Literature DB >> 12910270

Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss.

Konrad Noben-Trauth1, Qing Yin Zheng, Kenneth R Johnson.   

Abstract

Age-related hearing loss (AHL) in common inbred mouse strains is a genetically complex quantitative trait. We found a synonymous single-nucleotide polymorphism in exon 7 of Cdh23 that shows significant association with AHL and the deafness modifier mdfw (modifer of deafwaddler). The hypomorphic Cdh23(753A) allele causes in-frame skipping of exon 7. Altered adhesion or reduced stability of CDH23 may confer susceptibility to AHL. Homozygosity at Cdh23(753A) or in combination with heterogeneous secondary factors is a primary determinant of AHL in mice.

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Year:  2003        PMID： 12910270      PMCID： PMC2864026          DOI： 10.1038/ng1226

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

Review 1.  Molecular genetics of hearing loss.

Authors:  C Petit; J Levilliers; J P Hardelin
Journal:  Annu Rev Genet       Date:  2001       Impact factor: 16.830

2.  mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw).

Authors:  K Noben-Trauth; Q Y Zheng; K R Johnson; P M Nishina
Journal:  Genomics       Date:  1997-09-15       Impact factor: 5.736

3.  Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains.

Authors:  L C Erway; J F Willott; J R Archer; D E Harrison
Journal:  Hear Res       Date:  1993-02       Impact factor: 3.208

4.  Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.

Authors:  F Di Palma; R H Holme; E C Bryda; I A Belyantseva; R Pellegrino; B Kachar; K P Steel; K Noben-Trauth
Journal:  Nat Genet       Date:  2001-01       Impact factor: 38.330

5.  The BALB/c mouse as an animal model for progressive sensorineural hearing loss.

Authors:  J F Willott; J G Turner; S Carlson; D Ding; L Seegers Bross; W A Falls
Journal:  Hear Res       Date:  1998-01       Impact factor: 3.208

6.  A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice.

Authors:  K R Johnson; Q Y Zheng; L C Erway
Journal:  Genomics       Date:  2000-12-01       Impact factor: 5.736

7.  Identification and in vitro expression of novel CDH23 mutations of patients with Usher syndrome type 1D.

Authors:  Benigna von Brederlow; Hanno Bolz; Andreas Janecke; Alicia La O Cabrera; Günther Rudolph; Birgit Lorenz; Eberhard Schwinger; Andreas Gal
Journal:  Hum Mutat       Date:  2002-03       Impact factor: 4.878

8.  Genetic basis for susceptibility to noise-induced hearing loss in mice.

Authors:  R R Davis; J K Newlander; X Ling; G A Cortopassi; E F Krieg; L C Erway
Journal:  Hear Res       Date:  2001-05       Impact factor: 3.208

9.  A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice.

Authors:  K R Johnson; Q Y Zheng; Y Bykhovskaya; O Spirina; N Fischel-Ghodsian
Journal:  Nat Genet       Date:  2001-02       Impact factor: 38.330

10.  Plasma membrane Ca2+-ATPase extrudes Ca2+ from hair cell stereocilia.

Authors:  E N Yamoah; E A Lumpkin; R A Dumont; P J Smith; A J Hudspeth; P G Gillespie
Journal:  J Neurosci       Date:  1998-01-15       Impact factor: 6.167
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  203 in total

1.  Discovery Genetics - The History and Future of Spontaneous Mutation Research.

Authors:  Muriel T Davisson; David E Bergstrom; Laura G Reinholdt; Leah Rae Donahue
Journal:  Curr Protoc Mouse Biol       Date:  2012-06-01

2.  17th International Mouse Genome Conference.

Authors:  Ian Smyth; Tom Van Agtmael; Ian J Jackson
Journal:  Mamm Genome       Date:  2004-07       Impact factor: 2.957

Review 3.  Mitochondrial oxidative damage and apoptosis in age-related hearing loss.

Authors:  Shinichi Someya; Tomas A Prolla
Journal:  Mech Ageing Dev       Date:  2010-04-29       Impact factor: 5.432

4.  Alleles that modulate late life hearing in genetically heterogeneous mice.

Authors:  Jochen Schacht; Richard Altschuler; David T Burke; Shu Chen; David Dolan; Andrzej T Galecki; David Kohrman; Richard A Miller
Journal:  Neurobiol Aging       Date:  2012-02-02       Impact factor: 4.673

5.  Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.

Authors:  Avinash Jaiganesh; Pedro De-la-Torre; Aniket A Patel; Domenic J Termine; Florencia Velez-Cortes; Conghui Chen; Marcos Sotomayor
Journal:  Structure       Date:  2018-07-19       Impact factor: 5.006

Review 6.  Inheritance patterns of progressive hearing loss in laboratory strains of mice.

Authors:  Konrad Noben-Trauth; Kenneth R Johnson
Journal:  Brain Res       Date:  2009-02-21       Impact factor: 3.252

Review 7.  Application of Mouse Models to Research in Hearing and Balance.

Authors:  Kevin K Ohlemiller; Sherri M Jones; Kenneth R Johnson
Journal:  J Assoc Res Otolaryngol       Date:  2016-10-17

8.  Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.

Authors:  A Paul Nagtegaal; Robert N Rainey; Ingrid van der Pluijm; Renata M C Brandt; Gijsbertus T J van der Horst; J Gerard G Borst; Neil Segil
Journal:  J Neurosci       Date:  2015-03-11       Impact factor: 6.167

Review 9.  The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress.

Authors:  Verónica Miguel; Julia Yue Cui; Lidia Daimiel; Cristina Espinosa-Díez; Carlos Fernández-Hernando; Terrance J Kavanagh; Santiago Lamas
Journal:  Antioxid Redox Signal       Date:  2017-06-30       Impact factor: 8.401

10.  Hair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss.

Authors:  Mingqian Huang; Albena Kantardzhieva; Deborah Scheffer; M Charles Liberman; Zheng-Yi Chen
Journal:  J Neurosci       Date:  2013-09-18       Impact factor: 6.167
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