OBJECTIVES: To determine whether higher levels of inflammatory blood markers, D-dimer, and homocysteine were associated with greater impairment in lower extremity functioning in persons with peripheral arterial disease (PAD). DESIGN: Cross-sectional. SETTING: Three Chicago-area medical centers. PARTICIPANTS: Four hundred twenty-three persons with PAD (ankle-brachial index (ABI) <0.90). MEASUREMENTS: Lower extremity performance was assessed using the 6-minute walk and with usual- and fast-paced 4-m walking speed. Blood markers were D-dimer, C-reactive protein (CRP), interleukin-6 (IL-6), soluble vascular cellular adhesion molecule-1 (sVCAM-1), soluble intracellular adhesion molecule-1 (sICAM-1), and homocysteine. Calf muscle area was measured using computed tomography. RESULTS: Adjusting for confounders, higher levels of D-dimer (P<.001), IL-6 (P<.001), sVCAM-1 (P=.006), CRP (P=.01), homocysteine (P=.004), and sICAM-1 (P=.046) were associated with poorer 6-minute walk performance. Higher levels of D-dimer (P<.001), IL-6 (P=.003), sVCAM-1 (P=.001), and homocysteine (P=.005) were associated with slower usual-paced 4-m walking speed. Higher levels of D-dimer, sVCAM-1, sICAM-1, IL-6, and homocysteine were associated with slower fast-paced walking speed. Results were attenuated after additional adjustment for calf muscle area. CONCLUSION: Higher levels of inflammation and D-dimer were associated with poorer lower extremity performance in participants with PAD, independent of confounders including ABI.
OBJECTIVES: To determine whether higher levels of inflammatory blood markers, D-dimer, and homocysteine were associated with greater impairment in lower extremity functioning in persons with peripheral arterial disease (PAD). DESIGN: Cross-sectional. SETTING: Three Chicago-area medical centers. PARTICIPANTS: Four hundred twenty-three persons with PAD (ankle-brachial index (ABI) <0.90). MEASUREMENTS: Lower extremity performance was assessed using the 6-minute walk and with usual- and fast-paced 4-m walking speed. Blood markers were D-dimer, C-reactive protein (CRP), interleukin-6 (IL-6), soluble vascular cellular adhesion molecule-1 (sVCAM-1), soluble intracellular adhesion molecule-1 (sICAM-1), and homocysteine. Calf muscle area was measured using computed tomography. RESULTS: Adjusting for confounders, higher levels of D-dimer (P<.001), IL-6 (P<.001), sVCAM-1 (P=.006), CRP (P=.01), homocysteine (P=.004), and sICAM-1 (P=.046) were associated with poorer 6-minute walk performance. Higher levels of D-dimer (P<.001), IL-6 (P=.003), sVCAM-1 (P=.001), and homocysteine (P=.005) were associated with slower usual-paced 4-m walking speed. Higher levels of D-dimer, sVCAM-1, sICAM-1, IL-6, and homocysteine were associated with slower fast-paced walking speed. Results were attenuated after additional adjustment for calf muscle area. CONCLUSION: Higher levels of inflammation and D-dimer were associated with poorer lower extremity performance in participants with PAD, independent of confounders including ABI.
Authors: M M McDermott; S M Ohlmiller; K Liu; J M Guralnik; G J Martin; W H Pearce; P Greenland Journal: J Am Geriatr Soc Date: 2001-06 Impact factor: 5.562
Authors: Ramin Shadman; Michael H Criqui; Warner P Bundens; Arnost Fronek; Julie O Denenberg; Anthony C Gamst; Mary M McDermott Journal: J Am Coll Cardiol Date: 2004-08-04 Impact factor: 24.094
Authors: Mary McGrae McDermott; Kiang Liu; Philip Greenland; Jack M Guralnik; Michael H Criqui; Cheeling Chan; William H Pearce; Joseph R Schneider; Luigi Ferrucci; Lillian Celic; Lloyd M Taylor; Ed Vonesh; Gary J Martin; Elizabeth Clark Journal: JAMA Date: 2004-07-28 Impact factor: 56.272
Authors: Mary McGrae McDermott; Philip Greenland; David Green; Jack M Guralnik; Michael H Criqui; Kiang Liu; Cheeling Chan; William H Pearce; Lloyd Taylor; Paul M Ridker; Joseph R Schneider; Gary Martin; Nader Rifai; Maureen Quann; Myriam Fornage Journal: Circulation Date: 2003-06-16 Impact factor: 29.690
Authors: Mary McGrae McDermott; Philip Greenland; Kiang Liu; Jack M Guralnik; Lillian Celic; Michael H Criqui; Cheeling Chan; Gary J Martin; Joseph Schneider; William H Pearce; Lloyd M Taylor; Elizabeth Clark Journal: Ann Intern Med Date: 2002-06-18 Impact factor: 25.391
Authors: Stephen D Anton; Adam J Woods; Tetso Ashizawa; Diana Barb; Thomas W Buford; Christy S Carter; David J Clark; Ronald A Cohen; Duane B Corbett; Yenisel Cruz-Almeida; Vonetta Dotson; Natalie Ebner; Philip A Efron; Roger B Fillingim; Thomas C Foster; David M Gundermann; Anna-Maria Joseph; Christy Karabetian; Christiaan Leeuwenburgh; Todd M Manini; Michael Marsiske; Robert T Mankowski; Heather L Mutchie; Michael G Perri; Sanjay Ranka; Parisa Rashidi; Bhanuprasad Sandesara; Philip J Scarpace; Kimberly T Sibille; Laurence M Solberg; Shinichi Someya; Connie Uphold; Stephanie Wohlgemuth; Samuel Shangwu Wu; Marco Pahor Journal: Ageing Res Rev Date: 2015-10-14 Impact factor: 10.895
Authors: Andrew W Gardner; Polly S Montgomery; Ana I Casanegra; Federico Silva-Palacios; Zoltan Ungvari; Anna Csiszar Journal: Age (Dordr) Date: 2016-06-06
Authors: Jung Hye Sung; Jae Eun Lee; Tandaw E Samdarshi; Harsha S Nagarajarao; Jason K Taylor; Khushboo K Agrawal; Herman A Taylor; Ervin R Fox Journal: J Cardiovasc Med (Hagerstown) Date: 2014-05 Impact factor: 2.160
Authors: Todd M Manini; Stephen D Anton; Daniel P Beavers; Jane A Cauley; Mark A Espeland; Roger A Fielding; Stephen B Kritchevsky; Christiaan Leeuwenburgh; Kristina H Lewis; Christine Liu; Mary M McDermott; Michael E Miller; Russell P Tracy; Jeremy D Walston; Barbara Radziszewska; Jane Lu; Cindy Stowe; Samuel Wu; Anne B Newman; Walter T Ambrosius; Marco Pahor Journal: J Am Geriatr Soc Date: 2017-07-22 Impact factor: 5.562
Authors: Andrew W Gardner; Polly S Montgomery; Yan D Zhao; Zoltan Ungvari; Anna Csiszar; William E Sonntag Journal: Angiology Date: 2017-08-24 Impact factor: 3.619