OBJECTIVE: Systemic inflammation has been implicated as an early marker for subclinical cardiovascular disease; however, findings have been inconsistent in the African-American population. METHODS: We examined the relation of C-reactive protein (CRP) to subclinical disease in African-American participants of the Jackson Heart Study first examination. Subclinical disease evaluated included aortic valve calcification (AVC), carotid intima-medial thickness (IMT) and peripheral arterial disease (PAD). We assessed the relation of CRP to subclinical disease, adjusting for age, BMI, sex, SBP and DBP, diabetes, total/high-density lipoprotein cholesterol, triglycerides, smoking, antihypertensive therapy, lipid-lowering therapy and hormone replacement therapy. RESULTS: In the study population approximately, 5.1% of participants had AVC and 6.7% had PAD. In the age-adjusted and sex-adjusted model, CRP was significantly related to AVC (P = 0.02) and carotid IMT (P = 0.02). However, in the multivariable-adjusted logistic regression analysis, CRP was significantly related to AVC (P = 0.02) and to PAD (P = 0.04) but not to carotid IMT (P = 0.18). CONCLUSION: We describe significant associations between CRP and AVC and PAD in a population-based cohort of African-Americans.
OBJECTIVE:Systemic inflammation has been implicated as an early marker for subclinical cardiovascular disease; however, findings have been inconsistent in the African-American population. METHODS: We examined the relation of C-reactive protein (CRP) to subclinical disease in African-American participants of the Jackson Heart Study first examination. Subclinical disease evaluated included aortic valve calcification (AVC), carotid intima-medial thickness (IMT) and peripheral arterial disease (PAD). We assessed the relation of CRP to subclinical disease, adjusting for age, BMI, sex, SBP and DBP, diabetes, total/high-density lipoprotein cholesterol, triglycerides, smoking, antihypertensive therapy, lipid-lowering therapy and hormone replacement therapy. RESULTS: In the study population approximately, 5.1% of participants had AVC and 6.7% had PAD. In the age-adjusted and sex-adjusted model, CRP was significantly related to AVC (P = 0.02) and carotid IMT (P = 0.02). However, in the multivariable-adjusted logistic regression analysis, CRP was significantly related to AVC (P = 0.02) and to PAD (P = 0.04) but not to carotid IMT (P = 0.18). CONCLUSION: We describe significant associations between CRP and AVC and PAD in a population-based cohort of African-Americans.
Authors: Herman A Taylor; Bobby L Clark; Robert J Garrison; Michael E Andrew; Hui Han; Ervin R Fox; Donna K Arnett; Tandaw Samdarshi; Daniel W Jones Journal: Am J Cardiol Date: 2005-02-01 Impact factor: 2.778
Authors: Sonja R Fuqua; Sharon B Wyatt; Michael E Andrew; Daniel F Sarpong; Frances R Henderson; Margie F Cunningham; Herman A Taylor Journal: Ethn Dis Date: 2005 Impact factor: 1.847
Authors: Herman A Taylor; James G Wilson; Daniel W Jones; Daniel F Sarpong; Asoka Srinivasan; Robert J Garrison; Cheryl Nelson; Sharon B Wyatt Journal: Ethn Dis Date: 2005 Impact factor: 1.847
Authors: A E Hak; C D Stehouwer; M L Bots; K H Polderman; C G Schalkwijk; I C Westendorp; A Hofman; J C Witteman Journal: Arterioscler Thromb Vasc Biol Date: 1999-08 Impact factor: 8.311
Authors: Mika Kivimäki; Debbie A Lawlor; Markus Juonala; George Davey Smith; Marko Elovainio; Liisa Keltikangas-Järvinen; Jussi Vahtera; Jorma S A Viikari; Olli T Raitakari Journal: Arterioscler Thromb Vasc Biol Date: 2005-08-25 Impact factor: 8.311
Authors: D H O'Leary; J F Polak; R A Kronmal; S J Kittner; M G Bond; S K Wolfson; W Bommer; T R Price; J M Gardin; P J Savage Journal: Stroke Date: 1992-12 Impact factor: 7.914