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Literature DB >> 18661347

Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer.

Suniti Misra¹, Vincent C Hascall, Franklin G Berger, Roger R Markwald, Shibnath Ghatak.

Abstract

Carcinomas arising from colon epithelia develop or progress in a stromal microenvironment that is elevated in hyaluronan; interactions between elevated hyaluronan and the CD44 receptors on epithelial tumor cells activate an HA-receptor tyrosine kinase-mediated cell survival pathway. In this review we provide evidence that the hyaluronan-ErbB2-PI3kinase/AKT-ss-catenin-COX-2 signaling axis leads to intestinal epithelial and colon tumor cell division and proliferation. This review includes a summary of the authors work over the past years as well as citations of specific reviews related to role of hyaluronan in the pathogenesis of colon cancer.

Entities: Chemical Disease Gene

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Year: 2008 PMID： 18661347 DOI： 10.1080/03008200802143356

Source DB: PubMed Journal: Connect Tissue Res ISSN： 0300-8207 Impact factor: 3.417

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Cited

26 in total

1. V3 versican isoform alters the behavior of human melanoma cells by interfering with CD44/ErbB-dependent signaling.

Authors: Daniel Hernández; Laia Miquel-Serra; María-José Docampo; Anna Marco-Ramell; Jennifer Cabrera; Angels Fabra; Anna Bassols
Journal: J Biol Chem Date: 2010-11-15 Impact factor: 5.157

Review 2. Cancer stem cell detection and isolation.

Authors: Meysam Moghbeli; Faezeh Moghbeli; Mohammad Mahdi Forghanifard; Mohammad Reza Abbaszadegan
Journal: Med Oncol Date: 2014-07-27 Impact factor: 3.064

3. Stromal hyaluronan interaction with epithelial CD44 variants promotes prostate cancer invasiveness by augmenting expression and function of hepatocyte growth factor and androgen receptor.

Authors: Shibnath Ghatak; Vincent C Hascall; Roger R Markwald; Suniti Misra
Journal: J Biol Chem Date: 2010-03-03 Impact factor: 5.157

4. REDOX regulation of IL-13 signaling in intestinal epithelial cells: usage of alternate pathways mediates distinct gene expression patterns.

Authors: Debasmita Mandal; Pingfu Fu; Alan D Levine
Journal: Cell Signal Date: 2010-06-04 Impact factor: 4.315

5. Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway.

Authors: Rachna Kaul; Paramita Saha; Mallampati Saradhi; Ramachandra L A Prasad; Soumya Chatterjee; Ilora Ghosh; Rakesh K Tyagi; Kasturi Datta
Journal: J Biol Chem Date: 2012-03-26 Impact factor: 5.157

6. Overexpression of c-Met and CD44v6 receptors contributes to autocrine TGF-β1 signaling in interstitial lung disease.

Authors: Shibnath Ghatak; Galina S Bogatkevich; Ilia Atnelishvili; Tanjina Akter; Carol Feghali-Bostwick; Stanley Hoffman; Victor M Fresco; John C Fuchs; Richard P Visconti; Roger R Markwald; Subhas B Padhye; Richard M Silver; Vincent C Hascall; Suniti Misra
Journal: J Biol Chem Date: 2013-12-09 Impact factor: 5.157

Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer.

1. V3 versican isoform alters the behavior of human melanoma cells by interfering with CD44/ErbB-dependent signaling.

Review 2. Cancer stem cell detection and isolation.

3. Stromal hyaluronan interaction with epithelial CD44 variants promotes prostate cancer invasiveness by augmenting expression and function of hepatocyte growth factor and androgen receptor.

4. REDOX regulation of IL-13 signaling in intestinal epithelial cells: usage of alternate pathways mediates distinct gene expression patterns.

5. Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway.

6. Overexpression of c-Met and CD44v6 receptors contributes to autocrine TGF-β1 signaling in interstitial lung disease.

7. Differential Expression of Key Signaling Proteins in MCF10 Cell Lines, a Human Breast Cancer Progression Model.

8. Epithelial Ovarian Cancer and Cancer Stem Cells.

9. Periostin induces intracellular cross-talk between kinases and hyaluronan in atrioventricular valvulogenesis.

10. Novel findings about management of gastric cancer: a summary from 10th IGCC.