| Literature DB >> 34339028 |
Amr A Soliman1, Alaa A Elzarkaa2, Eduard Malik3.
Abstract
Epithelial ovarian cancer is a lethal gynecological cancer. It is related to high mortality because the majority of the patients present in advanced stage and because of the high recurrence rates of the disease. Recurrent ovarian cancer is classified according to the time interval between the last platinum-based chemotherapy and the occurrence of recurrence, to platinum-sensitive and platinum-resistant. Many theories tried to explain development of resistance to platinum-based therapy. "Cancer stem cells" is one of these theories and is being currently under investigation by many groups. This chapter will demonstrate the suggested contribution of cancer stem cells to the development of recurrent ovarian cancer.Entities:
Keywords: Cancer stem cells; Chemotherapy resistance; Ovarian cancer; Treatment
Year: 2021 PMID: 34339028 DOI: 10.1007/978-3-030-73359-9_2
Source DB: PubMed Journal: Adv Exp Med Biol ISSN: 0065-2598 Impact factor: 2.622