PURPOSE: The aim of this study was to investigate the regional differences between the morphologic and functional changes in the same patients with frontotemporal dementia (FTD) using statistical parametric mapping and voxel-based morphometry (VBM). METHODS: Thirteen FTD patients (mean age, 64.9 years old; mean MMSE score, 17.7), 20 sex-matched Alzheimer's disease (AD) patients (mean age, 65.0 years old; mean MMSE score, 17.5), and 20 normal volunteers (mean age, 65.2 years old; mean MMSE score, 29.0) underwent both [(18)F]FDG positron emission tomography and three-dimensional spoiled gradient echo MRI. Statistical parametric mapping was used to conduct a VBM analysis of the morphologic data, which were compared voxel by voxel with the results of a similar analysis of glucose metabolic data. RESULTS: FTD patients showed decreased grey matter volume and decreased glucose metabolism in the frontal lobe and anterior temporal lobe. In addition, there was a clear asymmetry in grey matter volume in FTD patients by the VBM analysis while the glucose metabolic data showed little asymmetry. In AD patients, glucose metabolic reduction occurred in the bilateral posterior cingulate gyri and parietal lobules while grey matter density decreased the least in the same patients. CONCLUSION: In FTD, metabolic and morphologic changes occur in the bilateral frontal lobe and temporal lobe with a limited asymmetry whereas there was considerable discordance in the AD group.
PURPOSE: The aim of this study was to investigate the regional differences between the morphologic and functional changes in the same patients with frontotemporal dementia (FTD) using statistical parametric mapping and voxel-based morphometry (VBM). METHODS: Thirteen FTDpatients (mean age, 64.9 years old; mean MMSE score, 17.7), 20 sex-matched Alzheimer's disease (AD) patients (mean age, 65.0 years old; mean MMSE score, 17.5), and 20 normal volunteers (mean age, 65.2 years old; mean MMSE score, 29.0) underwent both [(18)F]FDG positron emission tomography and three-dimensional spoiled gradient echo MRI. Statistical parametric mapping was used to conduct a VBM analysis of the morphologic data, which were compared voxel by voxel with the results of a similar analysis of glucose metabolic data. RESULTS:FTDpatients showed decreased grey matter volume and decreased glucose metabolism in the frontal lobe and anterior temporal lobe. In addition, there was a clear asymmetry in grey matter volume in FTDpatients by the VBM analysis while the glucose metabolic data showed little asymmetry. In ADpatients, glucose metabolic reduction occurred in the bilateral posterior cingulate gyri and parietal lobules while grey matter density decreased the least in the same patients. CONCLUSION: In FTD, metabolic and morphologic changes occur in the bilateral frontal lobe and temporal lobe with a limited asymmetry whereas there was considerable discordance in the AD group.
Authors: H J Rosen; M L Gorno-Tempini; W P Goldman; R J Perry; N Schuff; M Weiner; R Feiwell; J H Kramer; B L Miller Journal: Neurology Date: 2002-01-22 Impact factor: 9.910
Authors: An-Tao Du; Norbert Schuff; Joel H Kramer; Howard J Rosen; Maria Luisa Gorno-Tempini; Katherine Rankin; Bruce L Miller; Michael W Weiner Journal: Brain Date: 2007-03-12 Impact factor: 13.501
Authors: M Lindau; O Almkvist; J Kushi; K Boone; S E Johansson; L O Wahlund; J L Cummings; B L Miller Journal: Dement Geriatr Cogn Disord Date: 2000 Sep-Oct Impact factor: 2.959
Authors: Yong Jeong; Sang Soo Cho; Jung Mi Park; Sue J Kang; Jae Sung Lee; Eunjoo Kang; Duk L Na; Sang Eun Kim Journal: J Nucl Med Date: 2005-02 Impact factor: 10.057
Authors: Lisa Mosconi; Alberto Pupi; M Teresa R De Cristofaro; Mozghan Fayyaz; Sandro Sorbi; Karl Herholz Journal: J Nucl Med Date: 2004-03 Impact factor: 10.057
Authors: Yu Zhang; Maria Carmela Tartaglia; Norbert Schuff; Gloria C Chiang; Christopher Ching; Howard J Rosen; Maria Luisa Gorno-Tempini; Bruce L Miller; Michael W Weiner Journal: J Alzheimers Dis Date: 2013 Impact factor: 4.472
Authors: Kacie D Deters; Shannon L Risacher; Martin R Farlow; Frederick W Unverzagt; David A Kareken; Gary D Hutchins; Karmen K Yoder; Jill R Murrell; Salvatore Spina; Francine Epperson; Sujuan Gao; Andrew J Saykin; Bernardino Ghetti Journal: Am J Neurodegener Dis Date: 2014-12-05
Authors: Soichiro Shimizu; Yu Zhang; Joel Laxamana; Bruce L Miller; Joel H Kramer; Michael W Weiner; Norbert Schuff Journal: Brain Imaging Behav Date: 2010-03 Impact factor: 3.978
Authors: Alexander P Leff; Thomas M Schofield; Jennifer T Crinion; Mohamed L Seghier; Alice Grogan; David W Green; Cathy J Price Journal: Brain Date: 2009-12 Impact factor: 13.501