Literature DB >> 18660817

PlGF-MMP-9-expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle.

Cesare Gargioli1, Marcello Coletta, Fabrizio De Grandis, Stefano M Cannata, Giulio Cossu.   

Abstract

Sclerosis and reduced microvessel density characterize advanced stages of muscular dystrophy and hamper cell or gene delivery, precluding treatment of most individuals with Duchenne muscular dystrophy. Modified tendon fibroblasts expressing an angiogenic factor (placenta growth factor, PlGF) and a metalloproteinase (matrix metalloproteinase-9, MMP-9) are able to restore a vascular network and reduce collagen deposition, allowing efficient cell therapy in aged dystrophic mice. These data open the possibility of extending new therapies to currently untreatable individuals.

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Year:  2008        PMID： 18660817     DOI： 10.1038/nm.1852

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  60 in total

Review 1.  Role of matrix metalloproteinases in skeletal muscle: migration, differentiation, regeneration and fibrosis.

Authors:  Xiaoping Chen; Yong Li
Journal:  Cell Adh Migr       Date:  2009-10-24       Impact factor: 3.405

2.  Matrix metalloproteinase 9 is a distal-less 3 target-gene in placental trophoblast cells.

Authors:  Patricia A Clark; Jianjun Xie; Sha Li; Xuesen Zhang; Scott Coonrod; Mark S Roberson
Journal:  Am J Physiol Cell Physiol       Date:  2013-05-08       Impact factor: 4.249

3.  Multiscale models of skeletal muscle reveal the complex effects of muscular dystrophy on tissue mechanics and damage susceptibility.

Authors:  Kelley M Virgilio; Kyle S Martin; Shayn M Peirce; Silvia S Blemker
Journal:  Interface Focus       Date:  2015-04-06       Impact factor: 3.906

4.  Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor.

Authors:  Berta Vidal; Esther Ardite; Mònica Suelves; Vanessa Ruiz-Bonilla; Anna Janué; Matthew J Flick; Jay L Degen; Antonio L Serrano; Pura Muñoz-Cánoves
Journal:  Hum Mol Genet       Date:  2012-03-01       Impact factor: 6.150

Review 5.  Enhancing the efficacy of mesenchymal stem cell therapy.

Authors:  Michalis Mastri; Huey Lin; Techung Lee
Journal:  World J Stem Cells       Date:  2014-04-26       Impact factor: 5.326

Review 6.  Influence of exercise and aging on extracellular matrix composition in the skeletal muscle stem cell niche.

Authors:  Koyal Garg; Marni D Boppart
Journal:  J Appl Physiol (1985)       Date:  2016-08-18

Review 7.  Striated muscle function, regeneration, and repair.

Authors:  I Y Shadrin; A Khodabukus; N Bursac
Journal:  Cell Mol Life Sci       Date:  2016-06-06       Impact factor: 9.261

8.  The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates transforming growth factor (TGF)-β-dependent signaling, and inhibits TGF-β-dependent fibrotic response in skeletal muscles.

Authors:  Claudio Cabello-Verrugio; Cristian Santander; Catalina Cofré; Maria José Acuña; Francisco Melo; Enrique Brandan
Journal:  J Biol Chem       Date:  2011-12-27       Impact factor: 5.157

Review 9.  The effect of aging on the cutaneous microvasculature.

Authors:  Itay Bentov; May J Reed
Journal:  Microvasc Res       Date:  2015-04-24       Impact factor: 3.514

Review 10.  PlGF: a multitasking cytokine with disease-restricted activity.

Authors:  Mieke Dewerchin; Peter Carmeliet
Journal:  Cold Spring Harb Perspect Med       Date:  2012-08-01       Impact factor: 6.915
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